Your browser doesn't support javascript.
loading
A Comparison Between Early Presentation of Dementia with Lewy Bodies, Alzheimer's Disease, and Parkinson's Disease: Evidence from Routine Primary Care and UK Biobank Data.
Nedelec, Thomas; Couvy-Duchesne, Baptiste; Darves-Bornoz, Aube; Couronne, Raphaël; Monnet, Fleur; Gantzer, Laurène; Lekens, Béranger; Wu, Yeda; Villain, Nicolas; Schrag, Anette; Durrleman, Stanley; Corvol, Jean-Christophe.
Afiliación
  • Nedelec T; Sorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, Inria, Paris, France.
  • Couvy-Duchesne B; Sorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, Inria, Paris, France.
  • Darves-Bornoz A; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.
  • Couronne R; Sorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, Inria, Paris, France.
  • Monnet F; Sorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, Inria, Paris, France.
  • Gantzer L; Cegedim R&D, Boulogne-Billancourt, France.
  • Lekens B; Cegedim R&D, Boulogne-Billancourt, France.
  • Wu Y; Cegedim R&D, Boulogne-Billancourt, France.
  • Villain N; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.
  • Schrag A; Department of Neurology, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Durrleman S; Department of Clinical Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Corvol JC; Sorbonne Université, Paris Brain Institute-ICM, Inserm, CNRS, Inria, Paris, France.
Ann Neurol ; 94(2): 259-270, 2023 08.
Article en En | MEDLINE | ID: mdl-37098633
OBJECTIVE: The purpose of this study was to simultaneously contrast prediagnostic clinical characteristics of individuals with a final diagnosis of dementia with Lewy Bodies (DLB), Parkinson's disease (PD), and Alzheimer's disease (AD) compared with controls without neurodegenerative disorders. METHODS: Using the longitudinal THIN database in the United Kingdom, we tested the association of each neurodegenerative disorder with a selected list of symptoms and broad families of treatments, and compared the associations between disorders to detect disease-specific effects. We replicated the main findings in the UK Biobank. RESULTS: We used data of 28,222 patients with PD, 20,214 with AD, 4,682 with DLB, and 20,214 healthy controls. All neurodegenerative disorders were significantly associated with the presence of multiple clinical characteristics before their diagnosis, including sleep disorders, falls, psychiatric symptoms, and autonomic dysfunctions. When comparing patients with DLB with patients with PD and patients with AD patients, falls, psychiatric symptoms, and autonomic dysfunction were all more strongly associated with DLB in the 5 years preceding the first neurodegenerative diagnosis. The use of statins was lower in patients who developed PD and higher in patients who developed DLB compared to patients with AD. In patients with PD, the use of statins was associated with the development of dementia in the 5 years following PD diagnosis. INTERPRETATION: Prediagnostic presentations of falls, psychiatric symptoms, and autonomic dysfunctions were more strongly associated with DLB than PD and AD. This study also suggests that although several associations with medications are similar in neurodegenerative disorders, statin usage is negatively associated with PD but positively with DLB and AD as well as development of dementia in PD. ANN NEUROL 2023;94:259-270.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Enfermedad por Cuerpos de Lewy / Enfermedad de Alzheimer Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Ann Neurol Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Enfermedad por Cuerpos de Lewy / Enfermedad de Alzheimer Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Ann Neurol Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos