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Microparticles: potential new contributors to the pathogenesis of systemic sclerosis?
de Oliveira, Sandra Maximiano; de Azevedo Teixeira, Ighor Luiz; França, Carolina Nunes; de Oliveira Izar, Maria Cristina; Kayser, Cristiane.
Afiliación
  • de Oliveira SM; Rheumatology Division, Escola Paulista de Medicina, Federal University of São Paulo - UNIFESP, Rua Dos Otonis 863, 2º Andar, Vila Clementino, São Paulo, SP, 04025-002, Brazil.
  • de Azevedo Teixeira IL; Laboratory of Cellular and Molecular Biology - Lipids, Atherosclerosis and Vascular Biology Section, Cardiology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil.
  • França CN; Laboratory of Cellular and Molecular Biology - Lipids, Atherosclerosis and Vascular Biology Section, Cardiology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil.
  • de Oliveira Izar MC; Postgraduate Program in Health Sciences, Universidade de Santo Amaro - UNISA, São Paulo, Brazil.
  • Kayser C; Laboratory of Cellular and Molecular Biology - Lipids, Atherosclerosis and Vascular Biology Section, Cardiology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil.
Adv Rheumatol ; 63(1): 19, 2023 04 25.
Article en En | MEDLINE | ID: mdl-37098600
BACKGROUND: Microparticles (MPs) are membrane-derived vesicles released from cells undergoing activation or apoptosis with diverse proinflammatory and prothrombotic activities, that have been implicated in the pathogenesis of systemic sclerosis (SSc). We aimed to evaluate the plasma levels of platelet-derived microparticles (PMPs), endothelial cell-derived microparticles (EMPs), and monocyte-derived microparticles (MMPs) in SSc patients, and the association between MPs and the clinical features of SSc. METHODS: In this cross-sectional study, 70 patients with SSc and 35 age- and sex-matched healthy controls were evaluated. Clinical and nailfold capillaroscopy (NFC) data were obtained from all patients. Plasma levels of PMPs (CD42+/31+), EMPs (CD105+), and MMPs (CD14+) were quantified by flow cytometry. RESULTS: Patients were mainly females (90%), with a mean age of 48.9 years old. PMP, EMP, and MMP levels were significantly increased in SSc patients compared to controls (79.2% ± 17.3% vs. 71.0% ± 19.8%, p = 0.033; 43.5% ± 8.7% vs. 37.8% ± 10.4%, p = 0.004; and 3.5% ± 1.3% vs. 1.1% ± 0.5%, p < 0.0001, respectively). PMP levels were significantly higher in patients with positive anti-topoisomerase-I antibodies (p = 0.030) and in patients with a disease duration > 3 years (p = 0.038). EMP levels were lower in patients with a higher modified Rodnan skin score (p = 0.015), and in those with an avascular score > 1.5 in NFC (p = 0.042). CONCLUSION: The increased levels of PMPs, EMPs and MMPs in scleroderma patients might indicate a possible role for these agents in the pathogenesis of this challenging disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerodermia Sistémica / Micropartículas Derivadas de Células Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Adv Rheumatol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerodermia Sistémica / Micropartículas Derivadas de Células Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Adv Rheumatol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido