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N-3 PUFA Deficiency from Early Life to Adulthood Exacerbated Susceptibility to Reactive Oxygen Species-Induced Testicular Dysfunction in Adult Mice.
Zhao, Ying-Cai; Wang, Cheng-Cheng; Yang, Jin-Yue; Li, Xiao-Yue; Yanagita, Teruyoshi; Xue, Chang-Hu; Zhang, Tian-Tian; Wang, Yu-Ming.
Afiliación
  • Zhao YC; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, P. R. China.
  • Wang CC; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, P. R. China.
  • Yang JY; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, P. R. China.
  • Li XY; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, P. R. China.
  • Yanagita T; Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, Japan.
  • Xue CH; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, P. R. China.
  • Zhang TT; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237 Shandong Province, P. R. China.
  • Wang YM; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, Shandong, P. R. China.
J Agric Food Chem ; 71(18): 6908-6919, 2023 May 10.
Article en En | MEDLINE | ID: mdl-37098125
Homeostasis of reactive oxygen species is required to maintain sperm maturation and capacitation. Docosahexaenoic acid (DHA) is accumulated in testicles and spermatozoa and has the ability to manipulate the redox status. The effects of dietary n-3 polyunsaturated fatty acid (n-3 PUFA) deficiency from early life to adulthood on the physiological and functional properties of males under the redox imbalance of testicular tissue deserve attention. The consecutive injection of hydrogen peroxide (H2O2) and tert-butyl hydroperoxide (t-BHP) for 15 days to induce oxidative stress in testicular tissue was used to elucidate the consequences of testicular n-3 PUFA deficiency. The results indicated that reactive oxygen species treatment in adult male mice with DHA deficiency in the testis could reduce spermatogenesis and disrupt sex hormone production, as well as trigger testicular lipid peroxidation and tissue damage. N-3 PUFA deficiency from early life to adulthood resulted in higher susceptibility to testicular dysfunction in the germinal function of supplying germ cells and the endocrine role of secreting hormones through the mechanism of aggravating mitochondria-mediated apoptosis and destruction of blood testicular barrier under oxidative stress, which might provide a basis for humans to reduce susceptibility to chronic disease and maintain reproductive health in adulthood through dietary interventions of n-3 PUFAs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 Límite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 Límite: Animals / Humans / Male Idioma: En Revista: J Agric Food Chem Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos