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Online adaptive radiotherapy and dose delivery accuracy: A retrospective analysis.
Bessieres, Igor; Lorenzo, Olivier; Bertaut, Aurélie; Petitfils, Aurélie; Aubignac, Léone; Boudet, Julien.
Afiliación
  • Bessieres I; Department of Medical Physics, Centre Georges François Leclerc, Dijon, France.
  • Lorenzo O; Department of Medical Physics, Centre Georges François Leclerc, Dijon, France.
  • Bertaut A; Methodology, Data-Management and Biostatistics Unit, Centre Georges-François Leclerc, Dijon, France.
  • Petitfils A; Department of Medical Physics, Centre Georges François Leclerc, Dijon, France.
  • Aubignac L; Department of Medical Physics, Centre Georges François Leclerc, Dijon, France.
  • Boudet J; Department of Medical Physics, Centre Georges François Leclerc, Dijon, France.
J Appl Clin Med Phys ; 24(8): e14005, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37097765
PURPOSE: With online adaptive radiotherapy (ART), patient-specific quality assurance (PSQA) testing cannot be performed prior to delivery of the adapted treatment plan. Consequently, the dose delivery accuracy of adapted plans (i.e., the ability of the system to interpret and deliver the treatment as planned) are not initially verified. We investigated the variation in dose delivery accuracy of ART on the MRIdian 0.35 T MR-linac (Viewray Inc., Oakwood, USA) between initial plans and their respective adapted plans, by analyzing PSQA results. METHODS: We considered the two main digestive localizations treated with ART (liver and pancreas). A total of 124 PSQA results acquired with the ArcCHECK (Sun Nuclear Corporation, Melbourne, USA) multidetector system were analyzed. PSQA result variations between the initial plans and their respective adapted plans were statistically investigated and compared with the variation in MU number. RESULTS: For the liver, limited deterioration in PSQA results was observed, and was within the limits of clinical tolerance (Initial = 98.2%, Adapted = 98.2%, p = 0.4503). For pancreas plans, only a few significant deteriorations extending beyond the limits of clinical tolerance were observed and were due to specific, complex anatomical configurations (Initial = 97.3%, Adapted = 96.5%, p = 0.0721). In parallel, we observed an influence of the increase in MU number on the PSQA results. CONCLUSION: We show that the dose delivery accuracy of adapted plans, in terms of PSQA results, is preserved in ART processes on the 0.35 T MR-linac. Respecting good practices, and minimizing the increase in MU number can help to preserve the accuracy of delivery of adapted plans as compared to their respective initial plans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Planificación de la Radioterapia Asistida por Computador / Radioterapia de Intensidad Modulada Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: J Appl Clin Med Phys Asunto de la revista: BIOFISICA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Planificación de la Radioterapia Asistida por Computador / Radioterapia de Intensidad Modulada Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: J Appl Clin Med Phys Asunto de la revista: BIOFISICA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos