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Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review.
Gatica, Sebastian; Aravena, Diego; Echeverría, Cesar; Santibanez, Juan F; Riedel, Claudia A; Simon, Felipe.
Afiliación
  • Gatica S; Laboratory of Integrative Physiopathology, Faculty of Life Sciences, Universidad Andres Bello, Santiago, Chile. s.gaticafernandez@uandresbello.edu.
  • Aravena D; Millennium Institute on Immunology and Immunotherapy, Santiago, Chile. s.gaticafernandez@uandresbello.edu.
  • Echeverría C; Laboratory of Integrative Physiopathology, Faculty of Life Sciences, Universidad Andres Bello, Santiago, Chile.
  • Santibanez JF; Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.
  • Riedel CA; Laboratory of Molecular Biology, Nanomedicine and Genomics, Faculty of Medicine, University of Atacama, Copiapo, Chile.
  • Simon F; Institute for Medical Research, National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Adv Exp Med Biol ; 1408: 49-63, 2023.
Article en En | MEDLINE | ID: mdl-37093421
Catecholamine stimulation over adrenergic receptors results in a state of hypercoagulability. Chronic stress involves the release and increase in circulation of catecholamines and other stress related hormones. Numerous observational studies in human have related stressful scenarios to several coagulation variables, but controlled stimulation with agonists or antagonists to adrenergic receptors are scarce. This systematic review is aimed at presenting an updated appraisal of the effect of adrenergic receptor modulation on variables related to human hemostasis by systematically reviewing the effect of adrenergic receptor-targeting drugs on scale variables related to hemostasis. By searching 3 databases for articles published between January 1st 2011 and February 16th, 2022 reporting effects on coagulation parameters from stimulation with α- or ß-adrenergic receptor targeting drugs in humans regardless of baseline condition, excluding records different from original research and those not addressing the main aim of this systematic review. Risk of bias assessed using the Revised Cochrane risk-of-bias tool for randomized trials (RoB 2). Tables describing a pro-thrombotic anti-fibrinolytic state induced after ß-adrenergic receptor agonist stimulation and the opposite after α1-, ß-adrenergic receptor antagonist stimulation were synthesized from 4 eligible records by comparing hemostasis-related variables to their baseline. Notwithstanding this low number of records, experimental interventions included were sound and mostly unbiased, results were coherent, and outcomes were biologically plausible. In summary, this systematic review provides a critical systematic assessment and an updated elaboration, and its shortcomings highlight the need for further investigation in the field of hematology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Adrenérgicos / Adrenérgicos / Hemostasis Tipo de estudio: Clinical_trials / Observational_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Adv Exp Med Biol Año: 2023 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Adrenérgicos / Adrenérgicos / Hemostasis Tipo de estudio: Clinical_trials / Observational_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Adv Exp Med Biol Año: 2023 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Estados Unidos