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Quantitative Lipidomic Analysis of Serum Phospholipids Reveals Dissociable Markers of Alzheimer's Disease and Subcortical Cerebrovascular Disease.
Otoki, Yurika; Yu, Di; Shen, Qing; Sahlas, Demetrios J; Ramirez, Joel; Gao, Fuqiang; Masellis, Mario; Swartz, Richard H; Chan, Pak Cheung; Pettersen, Jacqueline A; Kato, Shunji; Nakagawa, Kiyotaka; Black, Sandra E; Swardfager, Walter; Taha, Ameer Y.
Afiliación
  • Otoki Y; Department of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA.
  • Yu D; Laboratory of Food Function Analysis, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan.
  • Shen Q; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada.
  • Sahlas DJ; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada.
  • Ramirez J; Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, Canada.
  • Gao F; LC Campbell Cognitive Neurology Unit, Sunnybrook Research Institute, Toronto, Canada.
  • Masellis M; Department of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA.
  • Swartz RH; Department of Medicine (Neurology Division), McMaster University, Hamilton, Canada.
  • Chan PC; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada.
  • Pettersen JA; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada.
  • Kato S; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada.
  • Nakagawa K; Department of Medicine (Neurology Division) and the Northern Medical Program, University of British Columbia, Vancouver, Canada.
  • Black SE; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada.
  • Swardfager W; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
  • Taha AY; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
J Alzheimers Dis ; 93(2): 665-682, 2023.
Article en En | MEDLINE | ID: mdl-37092220
BACKGROUND: Circulating phospholipid species have been shown to predict Alzheimer's disease (AD) prognosis but the link between phospholipid disturbances and subcortical small vessel cerebrovascular disease (CeVD) common in AD patients is not known. OBJECTIVE: Mass-spectrometry lipidomics was applied to quantify serum diacyl, alkenyl (ether), alkyl, and lyso phospholipid species in individuals with extensive CeVD (n = 29), AD with minimal CeVD (n = 16), and AD with extensive CeVD (n = 14), and compared them to age-matched controls (n = 27). Memory was assessed using the California Verbal Learning Test. 3.0T MRI was used to assess hippocampal volume, atrophy, and white matter hyperintensity (WMH) volumes as manifestations of CeVD. RESULTS: AD was associated with significantly higher concentrations of choline plasmalogen 18:0_18:1 and alkyl-phosphocholine 18:1. CeVD was associated with significantly lower lysophospholipids containing 16:0. Phospholipids containing arachidonic acid (AA) were associated with poorer memory in controls, whereas docosahexaenoic acid (DHA)-containing phospholipids were associated with better memory in individuals with AD+CeVD. In controls, DHA-containing phospholipids were associated with more atrophy, and phospholipids containing linoleic acid and AA were associated with less atrophy. Lysophospholipids containing 16:0, 18:0, and 18:1 were correlated with less atrophy in controls, and of these, alkyl-phosphocholine 18:1 was correlated with smaller WMH volumes. Conversely, 16:0_18:1 choline plasmalogen was correlated with greater WMH volumes in controls. CONCLUSION: This study demonstrates discernable differences in circulating phospholipids in individuals with AD and CeVD, as well as new associations between phospholipid species with memory and brain structure that were specific to contexts of commonly comorbid vascular and neurodegenerative pathologies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Cerebrovasculares / Enfermedad de Alzheimer / Sustancia Blanca Límite: Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Cerebrovasculares / Enfermedad de Alzheimer / Sustancia Blanca Límite: Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos