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Chronic alcohol administration alters metabolomic profile of murine bone marrow.
Pontes Pereira, Tássia Tatiane; Fideles Duarte-Andrade, Filipe; Gardone Vitório, Jéssica; do Espírito Santo Pereira, Taiane; Braga Martins, Flavia Rayssa; Marques Souza, Jéssica Amanda; Malacco, Nathália Luisa; Mathias Melo, Eliza; Costa Picossi, Carolina Raíssa; Pinto, Ernani; Santiago Gomez, Ricardo; Martins Teixeira, Mauro; Nori de Macedo, Adriana; André Baptista Canuto, Gisele; Soriani, Frederico Marianetti.
Afiliación
  • Pontes Pereira TT; Department of Genetics, Ecology and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Fideles Duarte-Andrade F; Department of Clinic, Pathology and Dental Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Gardone Vitório J; Department of Clinic, Pathology and Dental Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • do Espírito Santo Pereira T; Department of Analytical Chemistry of the Institute of Chemistry, Universidade Federal da Bahia, Salvador, Brazil.
  • Braga Martins FR; Department of Genetics, Ecology and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Marques Souza JA; Department of Genetics, Ecology and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Malacco NL; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
  • Mathias Melo E; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Costa Picossi CR; Chemistry Institute, University of São Paulo, São Paulo, Brazil.
  • Pinto E; Nuclear Energy Center in Agriculture, Escola Superior de Agricultura Luiz de Queiroz, University of São Paulo, Piracicaba, Brazil.
  • Santiago Gomez R; Department of Clinic, Pathology and Dental Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Martins Teixeira M; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Nori de Macedo A; Chemistry Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • André Baptista Canuto G; Department of Analytical Chemistry of the Institute of Chemistry, Universidade Federal da Bahia, Salvador, Brazil.
  • Soriani FM; Department of Genetics, Ecology and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Front Immunol ; 14: 1128352, 2023.
Article en En | MEDLINE | ID: mdl-37090737
Introduction: People with hazardous alcohol use are more susceptible to viral, bacterial, and fungal infections due to the effect of alcohol on immune system cell function. Metabolized ethanol reduces NAD+ to NADH, affecting critical metabolic pathways. Here, our aim was to investigate whether alcohol is metabolized by bone marrow cells and if it impacts the metabolic pathways of leukocyte progenitor cells. This is said to lead to a qualitative and quantitative alteration of key metabolites which may be related to the immune response. Methods: We addressed this aim by using C57BL/6 mice under chronic ethanol administration and evaluating the metabolomic profile of bone marrow total cells by gas chromatography-coupled mass spectrometry (GC-MS). Results: We identified 19 metabolites. Our data demonstrated that chronic ethanol administration alters the metabolomic profile in the bone marrow, resulting in a statistically diminished abundance of five metabolites in ethanol-treated animals: uracil, succinate, proline, nicotinamide, and tyrosine. Discussion: Our results demonstrate for the first time in the literature the effects of alcohol consumption on the metabolome content of hematopoietic tissue and open a wide range of further studies to investigate mechanisms by which alcohol compromises the cellular function of the immune system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Etanol Tipo de estudio: Qualitative_research Límite: Animals Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Etanol Tipo de estudio: Qualitative_research Límite: Animals Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza