Mechano-immunology in microgravity.

Murali, Anirudh; Sarkar, Ram Rup

Murali, Anirudh; Sarkar, Ram Rup.

Afiliación

Murali A; Chemical Engineering and Process Development, CSIR - National Chemical Laboratory, Pune, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Sarkar RR; Chemical Engineering and Process Development, CSIR - National Chemical Laboratory, Pune, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address: rr.sarkar@ncl.res.in.

Life Sci Space Res (Amst) ; 37: 50-64, 2023 May.

Article en En | MEDLINE | ID: mdl-37087179

RESUMEN

Life on Earth has evolved to thrive in the Earth's natural gravitational field; however, as space technology advances, we must revisit and investigate the effects of unnatural conditions on human health, such as gravitational change. Studies have shown that microgravity has a negative impact on various systemic parts of humans, with the effects being more severe in the human immune system. Increasing costs, limited experimental time, and sample handling issues hampered our understanding of this field. To address the existing knowledge gap and provide confidence in modelling the phenomena, in this review, we highlight experimental works in mechano-immunology under microgravity and different computational modelling approaches that can be used to address the existing problems.

Asunto(s)

Ingravidez; Humanos; Simulación por Computador; Planeta Tierra

Palabras clave

Computational modelling; Immune system; Mechano-immunology; Mechanotransduction; Microgravity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ingravidez Límite: Humans Idioma: En Revista: Life Sci Space Res (Amst) Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos

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