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A DBHS family member regulates male determination in the filariasis vector Armigeres subalbatus.
Liu, Peiwen; Yang, Wenqiang; Kong, Ling; Zhao, Siyu; Xie, Zhensheng; Zhao, Yijie; Wu, Yang; Guo, Yijia; Xie, Yugu; Liu, Tong; Jin, Binbin; Gu, Jinbao; Tu, Zhijian Jake; James, Anthony A; Chen, Xiao-Guang.
Afiliación
  • Liu P; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Yang W; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Kong L; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Zhao S; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Xie Z; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Zhao Y; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Wu Y; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Guo Y; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Xie Y; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Liu T; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Jin B; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Gu J; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Tu ZJ; Department of Biochemistry and the Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA, 24061, USA. jaketu@vt.edu.
  • James AA; Department of Microbiology & Molecular Genetics, University of California, Irvine, CA, 92697, USA. aajames@uci.edu.
  • Chen XG; Institute of Tropical Medicine, School of Public Health, Southern Medical University, Guangzhou, Guangdong, 510515, China. xgchen@smu.edu.cn.
Nat Commun ; 14(1): 2292, 2023 04 21.
Article en En | MEDLINE | ID: mdl-37085529
The initial signals governing sex determination vary widely among insects. Here we show that Armigeres subalbatus M factor (AsuMf), a male-specific duplication of an autosomal gene of the Drosophila behaviour/human splicing (DBHS) gene family, is the potential primary signal for sex determination in the human filariasis vector mosquito, Ar. subalbatus. Our results show that AsuMf satisfies two fundamental requirements of an M factor: male-specific expression and early embryonic expression. Ablations of AsuMf result in a shift from male- to female-specific splicing of doublesex and fruitless, leading to feminization of males both in morphology and general transcription profile. These data support the conclusion that AsuMf is essential for male development in Ar. subalbatus and reveal a male-determining factor that is derived from duplication and subsequent neofunctionalization of a member of the conserved DBHS family.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filariasis / Culicidae Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filariasis / Culicidae Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido