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[A role of neurosteroids in the pathogenesis of psychiatric disorders]. / Rol' neirosteroidov v patogeneze psikhicheskikh rasstroistv.
Petelin, D S; Bairamova, S P; Akhapkin, R V; Kudryashov, N V; Sorokina, O Yu; Semin, S A; Volel, B A.
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  • Petelin DS; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Bairamova SP; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Akhapkin RV; Serbsky National Medical Research Center of Psychiatry and Narcology, Moscow, Russia.
  • Kudryashov NV; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Sorokina OY; Zakusov Institute of Pharmacology, Moscow, Russia.
  • Semin SA; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Volel BA; «Spasenie¼ Clinic, LLC, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova ; 123(4): 31-36, 2023.
Article en Ru | MEDLINE | ID: mdl-37084362
Despite the proven importance of neurosteroids in many physiological processes, their role in the pathogenesis of the most of psychiatric disorders remains relatively understudied. This article reviews the current clinical evidence on the effects of neurosteroids on the formation and treatment of anxiety disorder, depression, bipolar disorder, and schizophrenia. In particular, the article points out the ambivalent nature of the effects of neurosteroids on GABAA- and other receptors. We are especially interested in the anxiolytic and anxiogenic effects of some neurosteroids, the antidepressant effect of allopregnanolone in treating postpartum and other forms of depression, and the nature of short- and long-term mechanisms of antidepressant effects of neurosteroids of different types. The currently unproven hypothesis about the effect of changes in the level of neurosteroids on the course of bipolar disorder is also discussed, with an analysis of the scientific evidence on the development of schizophrenic symptomatology in relation to changing neurosteroid levels in the context of positive and cognitive symptoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Neuroesteroides / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Female / Humans Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Neuroesteroides / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Female / Humans Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia