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Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency.
Shen, Jianlin; Lin, Xiaoning; Lin, Yujin; Xiao, Jiecheng; Wu, Changfu; Zheng, Feng; Wu, Xianwei; Lin, Haibin; Chen, Guoli; Liu, Huan.
Afiliación
  • Shen J; Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China.
  • Lin X; Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China.
  • Lin Y; Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China.
  • Xiao J; Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China.
  • Wu C; Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China.
  • Zheng F; Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China.
  • Wu X; Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China.
  • Lin H; Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China.
  • Chen G; Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China.
  • Liu H; Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China.
Front Nutr ; 10: 1026722, 2023.
Article en En | MEDLINE | ID: mdl-37081922
Objectives: There is still controversy about the effect of vitamin D supplementation on osteoarthritis (OA). The purpose of this study was to investigate the effects of vitamin D supplementation with Hyaluronic acid (HA) injection on OA. Methods: We investigated serum vitamin D levels and oxidative stress (OS) in synovial fluid from patients with OA who underwent total knee arthroplasty (grade IV, n = 24) and HA injection (grade II and III, n = 40). The effects of HA injection with or without oral vitamin D supplementation on synovial fluid OS and knee pain and function were then further investigated. Finally, patients underwent HA injection were divided into two groups according to vitamin D levels (vitamin D < or > 30 ng/ml), and the efficacy of the two groups were compared. Results: The results showed that the levels of glutathione peroxidase (GSH-PX) (P < 0.05) in the synovial fluid were lower in patients with stage IV OA than that in patients with stage II-III OA, while the levels of malondialdehyde (MDA) (P < 0.05) and lactate dehydrogenase (LDH) (P < 0.01) were significantly higher. Moreover, we found that age, BMI and vitamin D levels were significantly associated with the levels of oxidants and/or antioxidants in synovial fluid, and that vitamin D was significantly negatively correlated with BMI (R = -0.3527, p = 0.0043). Supplementation of HA injections with vitamin D significantly reduced the OS status in synovial fluid, attenuated knee pain and improved knee function in OA patients with vitamin D insufficiency. Conclusion: We conclude that maintenance of vitamin D sufficiency may be beneficial for the treatment of OA by improving OS in synovial fluid.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Nutr Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Nutr Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza