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Clinical Significance of Combining Preoperative and Postoperative Albumin-Bilirubin Score in Colorectal Cancer.
Kim, Doyoun; Lee, Jae-Hoon; Cho, Eun-Suk; Shin, Su-Jin; Lee, Hye Sun; Koh, Hwa-Hee; Lee, Kang Young; Kang, Jeonghyun.
Afiliación
  • Kim D; Yonsei University College of Medicine, Seoul, Korea.
  • Lee JH; Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Cho ES; Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Shin SJ; Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Lee HS; Biostatistic Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea.
  • Koh HH; Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Lee KY; Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Kang J; Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Cancer Res Treat ; 55(4): 1261-1269, 2023 Oct.
Article en En | MEDLINE | ID: mdl-37080608
PURPOSE: Albumin-bilirubin (ALBI) score is a well-known prognostic factor for various diseases, including colorectal cancer (CRC). However, little is known about the significance of postoperative ALBI score changes in patients with CRC. MATERIALS AND METHODS: A total of 723 patients who underwent surgery were enrolled. Preoperative ALBI (ALBI-pre) and postoperative ALBI (ALBI-post) scores were divided into low and high score groups. ALBI-trend was defined as a combination of four groups comprising the low and high ALBI-pre and ALBI-post score groups. Kaplan-Meier survival curves were used to compare the overall survival (OS) between the different ALBI groups. The Cox proportional hazards model was used to examine the independent relevant factors of OS. Stratification performance was compared between the different ALBI groupings using Harrell's concordance index (C-index). RESULTS: ALBI-pre, ALBI-post, and ALBI-trend score groups were significant prognostic factors of OS in the univariable analysis. However, multivariable analysis showed that ALBI-trend was an independent prognostic factor while ALBI-pre and ALBI-post were not. The C-index of ALBI-trend (0.622; 95% confidence interval [CI], 0.587 to 0.655) was higher than that of ALBI-pre (0.589; 95% CI, 0.557 to 0.621; bootstrap mean difference, 0.033; 95% CI, 0.013 to 0.057) and ALBI-post (0.575; 95% CI, 0.545 to 0.605; bootstrap mean difference, 0.047; 95% CI, 0.024 to 0.074). CONCLUSION: Combining ALBI-pre and ALBI-post scores is an independent prognostic factor of OS and shows superior predictive power compared to ALBI-pre or ALBI-post alone in patients with CRC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bilirrubina / Albúmina Sérica / Neoplasias Colorrectales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Res Treat Año: 2023 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bilirrubina / Albúmina Sérica / Neoplasias Colorrectales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Res Treat Año: 2023 Tipo del documento: Article Pais de publicación: Corea del Sur