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Anti-Lactosylceramide antibody positive combined central peripheral demyelination emerging from long-standing juvenile-onset chronic inflammatory polyradiculoneuropathy; a report of two cases.
Takegami, Naoki; Sakuishi, Kaori; Yamaguchi-Takegami, Nanaka; Egashira, Shuhei; Komaki, Shogo; Mutoh, Tatsuro; Toda, Tatsushi.
Afiliación
  • Takegami N; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.
  • Sakuishi K; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan; Department of Neurology, Teikyo University Chiba Medical Center, Chiba, Japan. Electronic address: ksakuishi@med.teikyo-u.ac.jp.
  • Yamaguchi-Takegami N; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.
  • Egashira S; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.
  • Komaki S; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.
  • Mutoh T; Department of Neurology, Fujita Health University Hospital, Aichi, Japan.
  • Toda T; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.
J Neuroimmunol ; 378: 578086, 2023 05 15.
Article en En | MEDLINE | ID: mdl-37079994
Anti-Lactosylceramide (LacCer) antibodies are associated with neurological inflammation involving both the peripheral and central nervous system (PNS, CNS respectively), however, the documented number of cases is small. Uncertainty remains whether its positivity can identify a unique clinical entity. Here, we describe two anti-LacCer antibody positive cases, both with long histories (> 30 years) of teenage-diagnosed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). CNS lesions including the medulla oblongata were observed for the first time in adulthood. We suggest that this secondary progression of CNS lesions in juvenile-onset CIDP can be one of the characteristic features of anti-LacCer antibody associated neurological disorder.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polirradiculoneuropatía / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Humans Idioma: En Revista: J Neuroimmunol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polirradiculoneuropatía / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Humans Idioma: En Revista: J Neuroimmunol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos