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Interactions between the lipidome and genetic and environmental factors in autism.
Yap, Chloe X; Henders, Anjali K; Alvares, Gail A; Giles, Corey; Huynh, Kevin; Nguyen, Anh; Wallace, Leanne; McLaren, Tiana; Yang, Yuanhao; Hernandez, Leanna M; Gandal, Michael J; Hansell, Narelle K; Cleary, Dominique; Grove, Rachel; Hafekost, Claire; Harun, Alexis; Holdsworth, Helen; Jellett, Rachel; Khan, Feroza; Lawson, Lauren P; Leslie, Jodie; Levis Frenk, Mira; Masi, Anne; Mathew, Nisha E; Muniandy, Melanie; Nothard, Michaela; Miller, Jessica L; Nunn, Lorelle; Strike, Lachlan T; Cadby, Gemma; Moses, Eric K; de Zubicaray, Greig I; Thompson, Paul M; McMahon, Katie L; Wright, Margaret J; Visscher, Peter M; Dawson, Paul A; Dissanayake, Cheryl; Eapen, Valsamma; Heussler, Helen S; Whitehouse, Andrew J O; Meikle, Peter J; Wray, Naomi R; Gratten, Jacob.
Afiliación
  • Yap CX; Mater Research Institute, The University of Queensland, Brisbane, Queensland, Australia. chloe.yap@uq.net.au.
  • Henders AK; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. chloe.yap@uq.net.au.
  • Alvares GA; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia. chloe.yap@uq.net.au.
  • Giles C; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
  • Huynh K; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Nguyen A; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Wallace L; Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
  • McLaren T; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
  • Yang Y; Baker Department of Cardiometabolic Health, The University of Melbourne, Melbourne, Victoria, Australia.
  • Hernandez LM; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
  • Gandal MJ; Baker Department of Cardiometabolic Health, The University of Melbourne, Melbourne, Victoria, Australia.
  • Hansell NK; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
  • Cleary D; Baker Department of Cardiometabolic Health, The University of Melbourne, Melbourne, Victoria, Australia.
  • Grove R; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
  • Hafekost C; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Harun A; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
  • Holdsworth H; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Jellett R; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
  • Khan F; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Lawson LP; Department of Psychiatry and Biobehavioral Sciences, Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Leslie J; Department of Psychiatry and Biobehavioral Sciences, Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Levis Frenk M; Lifespan Brain Institute at Penn Medicine and The Children's Hospital of Philadelphia, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
  • Masi A; Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Mathew NE; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Muniandy M; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
  • Nothard M; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Miller JL; Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
  • Nunn L; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Strike LT; Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.
  • Cadby G; School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
  • Moses EK; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • de Zubicaray GI; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Thompson PM; Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
  • McMahon KL; Mater Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
  • Wright MJ; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Visscher PM; Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
  • Dawson PA; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Dissanayake C; Olga Tennison Autism Research Centre, La Trobe University, Melbourne, Victoria, Australia.
  • Eapen V; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Heussler HS; School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
  • Whitehouse AJO; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Meikle PJ; Department of Psychology, Counselling and Therapy, La Trobe University, Melbourne, Victoria, Australia.
  • Wray NR; Cooperative Research Centre for Living with Autism, Long Pocket, Queensland, Australia.
  • Gratten J; Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
Nat Med ; 29(4): 936-949, 2023 04.
Article en En | MEDLINE | ID: mdl-37076741
Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep and feeding disorders) and the complex interplay between molecular profiles and neurodevelopment, genetics, environmental factors and health. Here we explored the plasma lipidome (783 lipid species) in 765 children (485 diagnosed with autism spectrum disorder (ASD)) within the Australian Autism Biobank. We identified lipids associated with ASD diagnosis (n = 8), sleep disturbances (n = 20) and cognitive function (n = 8) and found that long-chain polyunsaturated fatty acids may causally contribute to sleep disturbances mediated by the FADS gene cluster. We explored the interplay of environmental factors with neurodevelopment and the lipidome, finding that sleep disturbances and unhealthy diet have a convergent lipidome profile (with potential mediation by the microbiome) that is also independently associated with poorer adaptive function. In contrast, ASD lipidome differences were accounted for by dietary differences and sleep disturbances. We identified a large chr19p13.2 copy number variant genetic deletion spanning the LDLR gene and two high-confidence ASD genes (ELAVL3 and SMARCA4) in one child with an ASD diagnosis and widespread low-density lipoprotein-related lipidome derangements. Lipidomics captures the complexity of neurodevelopment, as well as the biological effects of conditions that commonly affect quality of life among autistic people.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Trastornos del Sueño-Vigilia / Trastorno del Espectro Autista Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Child / Humans País/Región como asunto: Oceania Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Trastornos del Sueño-Vigilia / Trastorno del Espectro Autista Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Child / Humans País/Región como asunto: Oceania Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos