Your browser doesn't support javascript.
loading
Giardia Detection and Codetection With Other Enteric Pathogens in Young Children in the Vaccine Impact on Diarrhea in Africa (VIDA) Case-Control Study: 2015-2018.
Marcenac, Perrine; Traoré, Awa; Kim, Sunkyung; Prentice-Mott, Graeme; Berendes, David M; Powell, Helen; Kasumba, Irene N; Nasrin, Dilruba; Jones, Joquina Chiquita M; Zaman, Syed M A; Ochieng, John B; Juma, Jane; Sanogo, Doh; Widdowson, Marc-Alain; Verani, Jennifer R; Liu, Jie; Houpt, Eric R; Jahangir Hossain, M; Sow, Samba O; Omore, Richard; Tennant, Sharon M; Mintz, Eric D; Kotloff, Karen L.
Afiliación
  • Marcenac P; Division of Foodborne, Waterborne, and Environmental Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Traoré A; Centre pour le Développement des Vaccins du Mali (CVD-Mali), Bamako, Mali.
  • Kim S; Division of Foodborne, Waterborne, and Environmental Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Prentice-Mott G; Division of Foodborne, Waterborne, and Environmental Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Berendes DM; Division of Foodborne, Waterborne, and Environmental Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Powell H; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Kasumba IN; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Nasrin D; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Jones JCM; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Zaman SMA; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Ochieng JB; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Juma J; Medical Research Council (UK) Unit, The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia.
  • Sanogo D; Medical Research Council (UK) Unit, The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia.
  • Widdowson MA; Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu, Kenya.
  • Verani JR; Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu, Kenya.
  • Liu J; Centre pour le Développement des Vaccins du Mali (CVD-Mali), Bamako, Mali.
  • Houpt ER; Division of Global Health Protection, Center for Global Health, Nairobi, Kenya.
  • Jahangir Hossain M; Division of Global Health Protection, Center for Global Health, Nairobi, Kenya.
  • Sow SO; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
  • Omore R; School of Public Health, Qingdao University, Qingdao, China.
  • Tennant SM; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
  • Mintz ED; Medical Research Council (UK) Unit, The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia.
  • Kotloff KL; Centre pour le Développement des Vaccins du Mali (CVD-Mali), Bamako, Mali.
Clin Infect Dis ; 76(76 Suppl1): S106-S113, 2023 04 19.
Article en En | MEDLINE | ID: mdl-37074432
BACKGROUND: Giardia has been associated with reduced risk of diarrhea in children in low-resource settings, but the mechanism underlying this association is unknown. To assess whether Giardia may shape colonization or infection with other enteric pathogens and impact associations with diarrhea, we examined Giardia and enteric pathogen codetection among children <5 years old in Kenya, The Gambia, and Mali as part of the Vaccine Impact on Diarrhea in Africa study. METHODS: We tested for Giardia and other enteric pathogens using enzyme-linked immunosorbent assays and real-time polymerase chain reaction (PCR) on stool, respectively. We evaluated associations between Giardia and enteric pathogen detection using multivariable logistic regression models separately for children with moderate-to-severe diarrhea (MSD, cases) and free of diarrhea (controls). RESULTS: Among 11 039 enrolled children, Giardia detection was more common among controls (35%) than cases (28%, P < .001). Campylobacter coli/jejuni detection was associated with Giardia in controls in The Gambia (adjusted odds ratio [aOR] [95% confidence interval {CI}]: 1.51 [1.22‒1.86]) and cases across all sites (1.16 [1.00‒1.33]). Among controls, the odds of astrovirus (1.43 [1.05‒1.93]) and Cryptosporidium spp. (1.24 [1.06‒1.46]) detection were higher among children with Giardia. Among cases, the odds of rotavirus detection were lower in children with Giardia in Mali (.45 [.30‒.66]) and Kenya (.31 [.17‒.56]). CONCLUSIONS: Giardia was prevalent in children <5 years old and was associated with detection of other enteric pathogens, with differing associations in cases versus controls and by site. Giardia may affect colonization or infection by certain enteric pathogens associated with MSD, suggesting an indirect mechanism of clinical impact.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / Criptosporidiosis / Cryptosporidium Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Humans / Infant País/Región como asunto: Africa Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / Criptosporidiosis / Cryptosporidium Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Humans / Infant País/Región como asunto: Africa Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos