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Evolution of Restriction-Modification Systems Consisting of One Restriction Endonuclease and Two DNA Methyltransferases.
Fokina, Anastasiya S; Karyagina, Anna S; Rusinov, Ivan S; Moshensky, Denis M; Spirin, Sergey A; Alexeevski, Andrey V.
Afiliación
  • Fokina AS; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119234, Russia.
  • Karyagina AS; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation, Moscow, 123098, Russia.
  • Rusinov IS; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.
  • Moshensky DM; All-Russia Research Institute of Agricultural Biotechnology, Moscow, 127550, Russia.
  • Spirin SA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.
  • Alexeevski AV; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119234, Russia.
Biochemistry (Mosc) ; 88(2): 253-261, 2023 Feb.
Article en En | MEDLINE | ID: mdl-37072330
Some restriction-modification systems contain two DNA methyltransferases. In the present work, we have classified such systems according to the families of catalytic domains present in the restriction endonucleases and both DNA methyltransferases. Evolution of the restriction-modification systems containing an endonuclease with a NOV_C family domain and two DNA methyltransferases, both with DNA_methylase family domains, was investigated in detail. Phylogenetic tree of DNA methyltransferases from the systems of this class consists of two clades of the same size. Two DNA methyltransferases of each restriction-modification system of this class belong to the different clades. This indicates independent evolution of the two methyltransferases. We detected multiple cross-species horizontal transfers of the systems as a whole, as well as the cases of gene transfer between the systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enzimas de Restricción-Modificación del ADN / Metiltransferasas Idioma: En Revista: Biochemistry (Mosc) Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enzimas de Restricción-Modificación del ADN / Metiltransferasas Idioma: En Revista: Biochemistry (Mosc) Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos