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[Formula: see text] Neural and behavioral indicators of cognitive control in preschoolers with and without prenatal opioid exposure.
Cárdenas, Emilia F; Hill, Kaylin E; Estes, Elizabeth; Ravi, Sanjana; Molnar, Andrew E; Humphreys, Kathryn L; Kujawa, Autumn.
Afiliación
  • Cárdenas EF; Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
  • Hill KE; Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
  • Estes E; Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
  • Ravi S; School of Social Work, University of Michigan, Ann Arbor, MI, USA.
  • Molnar AE; Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
  • Humphreys KL; Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Kujawa A; Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
Child Neuropsychol ; 30(2): 329-347, 2024 02.
Article en En | MEDLINE | ID: mdl-37070372
Prenatal opioid exposure is one consequence of the opioid epidemic, but effects on child development remain poorly understood. There is emerging evidence that children exposed to opioids in utero exhibit elevated emotional and behavioral problems, which may be partially due to alterations in cognitive control. Using multiple methods (i.e., neuropsychological, behavioral, and event-related potential [ERP] assessments), the present study examined differences in emotional, behavioral, and cognitive control difficulties in preschool-aged children with (n = 21) and without (n = 23) prenatal opioid exposure (Mage = 4.30, SD = 0.77 years). Child emotional and behavioral problems were measured with a caregiver questionnaire, indicators of cognitive control were measured using developmentally appropriate behavioral (i.e., delay discounting, Go/No-Go) and neuropsychological (i.e., Statue) tasks, and electroencephalogram was recorded to error and correct responses in a Go/No-Go task. ERP analyses focused on the error-related negativity (ERN), an ERP that reflects error monitoring, and correct-response negativity (CRN), a component reflecting performance monitoring more generally. Opioid exposure was associated with elevated difficulties across domains and a blunted ERN, reflecting altered cognitive control at the neural level, but groups did not significantly differ on behavioral measures of cognitive control. These result replicate prior studies indicating an association between prenatal opioid exposure and behavioral problems in preschool-aged children. Further, our findings suggest these differences may be partially due to children with prenatal opioid exposure exhibiting difficulties with cognitive control at the neural level. The ERN is a potential target for future research and intervention efforts to address the sequelae of prenatal opioid exposure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroencefalografía / Analgésicos Opioides Límite: Child / Child, preschool / Female / Humans / Pregnancy Idioma: En Revista: Child Neuropsychol Asunto de la revista: NEUROLOGIA / PSICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroencefalografía / Analgésicos Opioides Límite: Child / Child, preschool / Female / Humans / Pregnancy Idioma: En Revista: Child Neuropsychol Asunto de la revista: NEUROLOGIA / PSICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido