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An Image-Based Computational Fluid Dynamics Study of Mitral Regurgitation in Presence of Prolapse.
Bennati, Lorenzo; Vergara, Christian; Giambruno, Vincenzo; Fumagalli, Ivan; Corno, Antonio Francesco; Quarteroni, Alfio; Puppini, Giovanni; Luciani, Giovanni Battista.
Afiliación
  • Bennati L; Department of Surgery, Dentistry, Pediatrics, and Obstetrics/Gynecology, University of Verona, Piazzale Ludovico Antonio Scuro 10, 37134, Verona, Italy.
  • Vergara C; LaBS, Dipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy. christian.vergara@polimi.it.
  • Giambruno V; Division of Cardiac Surgery, Department of Surgery, Dentistry, Pediatrics, and Obstetrics/Gynecology, University of Verona, O. C. M. Piazzale Stefani 1, 37126, Verona, Italy.
  • Fumagalli I; MOX, Dipartimento di Matematica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy.
  • Corno AF; Children's Heart Institute, McGovern Medical School, UT Health, 6431 Fannin Street, Houston, TX, 77030, USA.
  • Quarteroni A; MOX, Dipartimento di Matematica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy.
  • Puppini G; École Polytechnique Fédérale de Lausanne, Rte Cantonale, 1015, Lausanne, Switzerland.
  • Luciani GB; Department of Radiology, University of Verona, O. C. M. Piazzale Stefani 1, 37126, Verona, Italy.
Cardiovasc Eng Technol ; 14(3): 457-475, 2023 06.
Article en En | MEDLINE | ID: mdl-37069336
PURPOSE: In this work we performed an imaged-based computational study of the systolic fluid dynamics in presence of mitral valve regurgitation (MVR). In particular, we compared healthy and different regurgitant scenarios with the aim of quantifying different hemodynamic quantities. METHODS: We performed computational fluid dynamic (CFD) simulations in the left ventricle, left atrium and aortic root, with a resistive immersed method, a turbulence model, and with imposed systolic wall motion reconstructed from Cine-MRI images, which allowed us to segment also the mitral valve. For the regurgitant scenarios we considered an increase of the heart rate and a dilation of the left ventricle. RESULTS: Our results highlighted that MVR gave rise to regurgitant jets through the mitral orifice impinging against the atrial walls and scratching against the mitral valve leading to high values of wall shear stresses (WSSs) with respect to the healthy case. CONCLUSION: CFD with prescribed wall motion and immersed mitral valve revealed to be an effective tool to quantitatively describe hemodynamics in case of MVR and to compare different regurgitant scenarios. Our findings highlighted in particular the presence of transition to turbulence in the atrium and allowed us to quantify some important cardiac indices such as cardiac output and WSS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia de la Válvula Mitral Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cardiovasc Eng Technol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia de la Válvula Mitral Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cardiovasc Eng Technol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos