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Asthma Prevalence and Phenotyping in the General Population: The LEAD (Lung, hEart, sociAl, boDy) Study.
Schiffers, Caspar; Wouters, Emiel F M; Breyer-Kohansal, Robab; Buhl, Roland; Pohl, Wolfgang; Irvin, Charles G; Breyer, Marie-Kathrin; Hartl, Sylvia.
Afiliación
  • Schiffers C; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.
  • Wouters EFM; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.
  • Breyer-Kohansal R; NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.
  • Buhl R; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.
  • Pohl W; Department of Respiratory and Pulmonary Diseases, Clinic Hietzing, Vienna Healthcare Group, Vienna, Austria.
  • Irvin CG; Pulmonology Department, Mainz University Hospital, Mainz, Germany.
  • Breyer MK; Karl Landsteiner Gesellschaft, Institute for Clinical and Experimental Pneumology, Vienna, Austria.
  • Hartl S; Pulmonary and Critical Care, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
J Asthma Allergy ; 16: 367-382, 2023.
Article en En | MEDLINE | ID: mdl-37063243
Background: Asthma is a chronic heterogeneous respiratory disease involving differential pathophysiological pathways and consequently distinct asthma phenotypes. Objective and Methods: In the LEAD Study, a general population cohort (n=11.423) in Vienna ranging from 6-82 years of age, we addressed the prevalence of asthma and explored inflammatory asthma phenotypes that included allergic and non-allergic asthma, and within these phenotypes, an eosinophilic (eosinophils ≥300 cells/µL, or ≥150 cells/µL in the presence of ICS medication) or non-eosinophilic (eosinophils <300 cells/µL, or <150 cells/µL in the presence of ICS) phenotype. In addition, we compared various factors related to biomarkers, body composition, lung function, and symptoms in control subjects versus subjects with current asthma (current doctor's diagnosis of asthma). Results: An overall prevalence of 4.6% was observed for current asthma. Furthermore, an age-dependent shift from allergic to non-allergic asthma was found. The non-eosinophilic phenotype was more prominent. Obesity was a prevalent condition, and body composition including visceral adipose tissue (VAT), is affected in current asthma versus controls. Conclusion: This broad-aged and large general population cohort identified differential patterns of inflammatory asthma phenotypes that were age-dependent. The presence of eosinophilia was associated with worse asthma control, increased asthma medication, increased VAT, and lower lung function, the opposite was found for the presence of an allergic asthma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prevalence_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Asthma Allergy Año: 2023 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prevalence_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Asthma Allergy Año: 2023 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Nueva Zelanda