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Role of Systemic Inflammatory Markers in Pediatric Kidney Transplantation.
Taner, Sevgin; Goktepe, Berk; Zaman, Ece Irem; Asci, Gulay; Bulut, Ipek Kaplan; Toz, Huseyin; Sarsik, Banu; Firat, Ozgur; Kizilkaya, Ali Ekber; Kabasakal, Caner; Keskinoglu, Ahmet.
Afiliación
  • Taner S; Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkey.
  • Goktepe B; General Surgery, Ege University Faculty of Medicine, Izmir, Turkey.
  • Zaman EI; Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
  • Asci G; Nephrology, Ege University Faculty of Medicine, Izmir, Turkey.
  • Bulut IK; Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkey. Electronic address: ikaplanbulut@gmail.com.
  • Toz H; Nephrology, Ege University Faculty of Medicine, Izmir, Turkey.
  • Sarsik B; Pathology, Ege University Faculty of Medicine, Izmir, Turkey.
  • Firat O; General Surgery, Ege University Faculty of Medicine, Izmir, Turkey.
  • Kizilkaya AE; Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
  • Kabasakal C; Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkey.
  • Keskinoglu A; Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkey.
Transplant Proc ; 55(5): 1152-1155, 2023 Jun.
Article en En | MEDLINE | ID: mdl-37062614
BACKGROUND: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII = N × P/L), and neutrophil percentage-albumin ratio (NPAR) have become accepted markers of inflammation in recent years. These indices are used as indicators of disease activity, mortality, and morbidity in many diseases. This study evaluated the relationship between inflammatory indices and graft function in pediatric kidney transplant recipients. METHODS: Medical records of pediatric patients who underwent kidney transplantation at Ege University between 1995 and 2020 were reviewed retrospectively. Demographic, clinical, and laboratory data were recorded during the third month, first year, and fifth year of transplantation and at the last visit. RESULTS: The median age of the 119 patients (60 boys/59 girls) at the time of transplantation was 154 months, and the median follow-up period was 101 months. According to Spearman correlation analysis, patients' final creatinine levels were positively correlated with NLR (r = 0.319), PLR (r = 0.219), SII (r = 0.214), and NPAR (r = 0.347) of the last visit; final estimate glomerular filtration rate levels were negatively correlated with NLR (P = .010, r = -0.250) and NPAR (P = .004, r = -0.277). The median NPAR of the patients with chronic allograft dysfunction at the last visit was found to be statistically significantly higher than without (P = .032). CONCLUSION: NLR, PLR, SII, and NPAR values are correlated with creatinine levels after 5 years of kidney transplantation. The NPAR and final creatinine levels had the highest correlation coefficient among these inflammatory markers. These results suggest that inflammatory markers, especially NPAR, may be a candidate to be an indicator of ongoing inflammation in the graft.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón Tipo de estudio: Observational_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Transplant Proc Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón Tipo de estudio: Observational_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Transplant Proc Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos