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From observational to actionable: rethinking omics in biologics production.
Masson, Helen O; Karottki, Karen Julie la Cour; Tat, Jasmine; Hefzi, Hooman; Lewis, Nathan E.
Afiliación
  • Masson HO; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
  • Karottki KJC; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
  • Tat J; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA; Amgen Inc., Thousand Oaks, CA, USA.
  • Hefzi H; Biogen, Inc., Cambridge, MA, USA. Electronic address: hooman.hefzi@biogen.com.
  • Lewis NE; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA. Electronic address: nlewisres@ucsd.edu.
Trends Biotechnol ; 41(9): 1127-1138, 2023 09.
Article en En | MEDLINE | ID: mdl-37062598
As the era of omics continues to expand with increasing ubiquity and success in both academia and industry, omics-based experiments are becoming commonplace in industrial biotechnology, including efforts to develop novel solutions in bioprocess optimization and cell line development. Omic technologies provide particularly valuable 'observational' insights for discovery science, especially in academic research and industrial R&D; however, biomanufacturing requires a different paradigm to unlock 'actionable' insights from omics. Here, we argue the value of omic experiments in biotechnology can be maximized with deliberate selection of omic approaches and forethought about analysis techniques. We describe important considerations when designing and implementing omic-based experiments and discuss how systems biology analysis strategies can enhance efforts to obtain actionable insights in mammalian-based biologics production.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos Límite: Animals Idioma: En Revista: Trends Biotechnol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos Límite: Animals Idioma: En Revista: Trends Biotechnol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido