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Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring.
Nash, Michael J; Dobrinskikh, Evgenia; Soderborg, Taylor K; Janssen, Rachel C; Takahashi, Diana L; Dean, Tyler A; Varlamov, Oleg; Hennebold, Jon D; Gannon, Maureen; Aagaard, Kjersti M; McCurdy, Carrie E; Kievit, Paul; Bergman, Bryan C; Jones, Kenneth L; Pietras, Eric M; Wesolowski, Stephanie R; Friedman, Jacob E.
Afiliación
  • Nash MJ; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Dobrinskikh E; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Soderborg TK; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Janssen RC; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
  • Takahashi DL; Division of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Dean TA; Division of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Varlamov O; Division of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Hennebold JD; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Gannon M; Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN 37235, USA.
  • Aagaard KM; Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
  • McCurdy CE; Department of Human Physiology, University of Oregon, Eugene, OR 97403, USA.
  • Kievit P; Division of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Bergman BC; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Jones KL; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
  • Pietras EM; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Wesolowski SR; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Friedman JE; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Electronic address: jed-friedman@ouhsc.edu.
Cell Rep ; 42(4): 112393, 2023 04 25.
Article en En | MEDLINE | ID: mdl-37058409
Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal offspring. This constitutes a major public health concern due to increasing prevalence of these diseases, yet mechanisms remain unclear. Here, using nonhuman primate models, we show that maternal Western-style diet (mWSD) exposure is associated with persistent pro-inflammatory phenotypes at the transcriptional, metabolic, and functional levels in bone marrow-derived macrophages (BMDMs) from 3-year-old juvenile offspring and in hematopoietic stem and progenitor cells (HSPCs) from fetal and juvenile bone marrow and fetal liver. mWSD exposure is also associated with increased oleic acid in fetal and juvenile bone marrow and fetal liver. Assay for transposase-accessible chromatin with sequencing (ATAC-seq) profiling of HSPCs and BMDMs from mWSD-exposed juveniles supports a model in which HSPCs transmit pro-inflammatory memory to myeloid cells beginning in utero. These findings show that maternal diet alters long-term immune cell developmental programming in HSPCs with proposed consequences for chronic diseases featuring altered immune/inflammatory activation across the lifespan.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Células Madre Hematopoyéticas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Cell Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Células Madre Hematopoyéticas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Revista: Cell Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos