Supplementing culture medium with the weak acid, 5,5-dimethyl-2,4-oxazolidinedione (DMO) limits the development of aneuploid mouse embryos through a Trp53-dependent mechanism.

Lowther, Katie M; Bartolucci, Alison F; Massey, Rachael E; Brown, Judy; Peluso, John J

Supplementing culture medium with the weak acid, 5,5-dimethyl-2,4-oxazolidinedione (DMO) limits the development of aneuploid mouse embryos through a Trp53-dependent mechanism.

Lowther, Katie M; Bartolucci, Alison F; Massey, Rachael E; Brown, Judy; Peluso, John J.

Afiliación

Lowther KM; Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Ave., CT, 06030, Farmington, USA.
Bartolucci AF; Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, CT, 06030, USA.
Massey RE; The Center for Advanced Reproductive Services, University of Connecticut Health Center, Farmington, CT, 06030, USA.
Brown J; Institute for Systems Genomics, UCONN, Storrs, CT, 06268, USA.
Peluso JJ; Institute for Systems Genomics, UCONN, Storrs, CT, 06268, USA.

J Assist Reprod Genet ; 40(5): 1215-1223, 2023 May.

Article en En | MEDLINE | ID: mdl-37058262

Asunto(s)

Blastocisto; Dimetadiona; Ratones; Animales; Dimetadiona/metabolismo; Blastocisto/metabolismo; Aneuploidia; ARN Mensajero/metabolismo; Medios de Cultivo/farmacología; Medios de Cultivo/metabolismo; Desarrollo Embrionario/genética

Palabras clave

Aneuploidy; Blastocyst development; In vitro; Trp53

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Blastocisto / Dimetadiona Límite: Animals Idioma: En Revista: J Assist Reprod Genet Asunto de la revista: GENETICA / MEDICINA REPRODUTIVA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google