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Adjunctive effects of photodynamic therapy using indocyanine green in residual pockets during periodontal maintenance therapy: A split-mouth randomized controlled trial.
Costa, Fernando Oliveira; Esteves Lima, Rafael Paschoal; Costa, Adriana Moreira; Costa, Amanda Almeida; Mattos Pereira, Gustavo Henrique; Cortelli, Sheila Cavalca; Cortelli, José Roberto; Magalhães Cyrino, Renata; Aparecida Silva, Tarcília; Miranda Cota, Luís Otávio.
Afiliación
  • Costa FO; School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Esteves Lima RP; School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Costa AM; Department of Periodontics, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Costa AA; School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Mattos Pereira GH; School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Cortelli SC; Department of Dentistry, Periodontics Research Division, University of Taubaté, São Paulo, Brazil.
  • Cortelli JR; Department of Dentistry, Periodontics Research Division, University of Taubaté, São Paulo, Brazil.
  • Magalhães Cyrino R; School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Aparecida Silva T; School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Miranda Cota LO; School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
J Periodontol ; 94(9): 1100-1111, 2023 09.
Article en En | MEDLINE | ID: mdl-37051740
BACKGROUND: Prospective studies have reported conflicting results regarding the adjunctive effect of antimicrobial photodynamic therapy (aPDT) on clinical and microbiological parameters in individuals under periodontal maintenance therapy (PMT). This study aimed to evaluate the clinical and microbiological adjunctive effects of aPDT using indocyanine green (ICG) in residual sites with probing depth (PD) ≥5 mm during PMT in comparison with scaling and root planing (SRP) alone. METHODS: A split-mouth randomized controlled clinical trial was conducted with 24 individuals in a PMT program. Contralateral quadrants with eligible residual sites were randomly assigned to either SRP + aPDT (test group) or SRP alone (control). aPDT included ICG dye and diode laser (909 nm) performed together with SRP and repeated 15 days after. Periodontal clinical parameters, periodontal inflamed surface area (PISA) index, and subgingival biofilm samples were collected at baseline (T1), 3 (T2), and 6 months later (T3). Microbiological analyses were performed by quantitative real-time polymerase chain reaction. RESULTS: Significant improvements were observed in all clinical and microbiological parameters in both groups from T1 to T3. However, no significant differences were observed regarding plaque index, PD, and clinical attachment level. Test group showed significantly greater reductions in bleeding on probing (BOP), PISA index, and Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans levels, when compared with controls. CONCLUSIONS: Both treatments resulted in significant clinical periodontal improvements, but with no significant differences between groups except from inflammation parameters. aPDT using ICG resulted in significant reductions in BOP and PISA index, as well as in P. gingivalis and A. actinomycetemcomitans levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Periodontitis Crónica Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Periodontol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Periodontitis Crónica Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Periodontol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos