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Serum metabolic alterations in peritoneal dialysis patients with excessive daytime sleepiness.
Chen, Wei; Xu, Ying; Li, Zheng-Hao; Si, Ya-Chen; Wang, Hai-Yan; Bian, Xiao-Lu; Li, Lu; Guo, Zhi-Yong; Lai, Xue-Li.
Afiliación
  • Chen W; Department of Nephrology, Shanghai Changhai Hospital, Shanghai, P.R. China.
  • Xu Y; Department of Nephrology, Shanghai Changhai Hospital, Shanghai, P.R. China.
  • Li ZH; Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Military of Education, Naval Medical University, Shanghai, P.R. China.
  • Si YC; Department of Nephrology, Shanghai Changhai Hospital, Shanghai, P.R. China.
  • Wang HY; Department of Nephrology, Shanghai Changhai Hospital, Shanghai, P.R. China.
  • Bian XL; Department of Nephrology, Shanghai Changhai Hospital, Shanghai, P.R. China.
  • Li L; Department of Nephrology, Shanghai Changhai Hospital, Shanghai, P.R. China.
  • Guo ZY; Department of Nephrology, Shanghai Changhai Hospital, Shanghai, P.R. China.
  • Lai XL; Department of Nephrology, Shanghai Changhai Hospital, Shanghai, P.R. China.
Ren Fail ; 45(1): 2190815, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37051665
Excessive daytime sleepiness (EDS) is associated with quality of life and all-cause mortality in the end-stage renal disease population. This study aims to identify biomarkers and reveal the underlying mechanisms of EDS in peritoneal dialysis (PD) patients. A total of 48 nondiabetic continuous ambulatory peritoneal dialysis patients were assigned to the EDS group and the non-EDS group according to the Epworth Sleepiness Scale (ESS). Ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) was used to identify the differential metabolites. Twenty-seven (male/female, 15/12; age, 60.1 ± 16.2 years) PD patients with ESS ≥ 10 were assigned to the EDS group, while twenty-one (male/female, 13/8; age, 57.9 ± 10.1 years) PD patients with ESS < 10 were defined as the non-EDS group. With UHPLC-Q-TOF/MS, 39 metabolites with significant differences between the two groups were found, 9 of which had good correlations with disease severity and were further classified into amino acid, lipid and organic acid metabolism. A total of 103 overlapping target proteins of the differential metabolites and EDS were found. Then, the EDS-metabolite-target network and the protein-protein interaction network were constructed. The metabolomics approach integrated with network pharmacology provides new insights into the early diagnosis and mechanisms of EDS in PD patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Peritoneal / Diálisis Peritoneal Ambulatoria Continua / Trastornos de Somnolencia Excesiva / Fallo Renal Crónico Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Screening_studies Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Peritoneal / Diálisis Peritoneal Ambulatoria Continua / Trastornos de Somnolencia Excesiva / Fallo Renal Crónico Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Screening_studies Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido