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Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells.
Lin, Chia-Kai; Chen, Bor-Yann; Ting, Jasmine U; Rogio, Kristian Gil G; Tsai, Po-Wei; Liu, Yung-Chuan.
Afiliación
  • Lin CK; Department of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan.
  • Chen BY; Department of Chemical and Materials Engineering, National I-Lan University, I-Lan 260, Taiwan.
  • Ting JU; Department of Chemistry, College of Science, De La Salle University, Metro Manila 1004, Philippines.
  • Rogio KGG; School of Chemical, Biological, and Materials Engineering and Sciences, Mapúa University, Metro Manila 1002, Philippines.
  • Tsai PW; Department of Medical Science Industries, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan.
  • Liu YC; Department of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan.
J Taiwan Inst Chem Eng ; 145: 104838, 2023 Apr.
Article en En | MEDLINE | ID: mdl-37051508
Background: Traditional herbal medicines usually contain electron shuttle (ES)-like structures compounds which are potential candidates for antiviral compounds selection. Houttuynia cordata is applied as a biomaterial to decipher its potential applications in bioenergy extraction in microbial fuel cells (MFCs) and anti-COVID-19 via molecular docking evaluation. Methods: H. cordata leaves extracts by water and 60% ethanol solvent were analyzed for total polyphenols, antioxidant activity, cyclic voltammetry (CV), and MFCs. The bioactive compounds of H. cordata leaves extracts were assayed via LC/MS analysis. Identification of the marker substances for potential antiviral activity using a molecular docking model was provided. Significant findings: 60% ethanol extract exhibits the highest total polyphenols and antioxidant activity compared with water extracts. Bioenergy extraction in MFCs showed that 60% ethanol extracts could give 1.76-fold more power generation compared to the blank. Flavonoids and their sugar-to-glycan ratios increased after CV scanning and they are expected to be effective ES substances. Quercitrin, from the H. cordata extract that shares an ES-like structure, was found to exhibit strong binding affinities towards ACE2 and RdRp. This indicated the potential of H. cordata leaves as a promising antiviral herb.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Taiwan Inst Chem Eng Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Taiwan Inst Chem Eng Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos