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Expression of Cytokines and Neurodegeneration in the Rat Hippocampus and Cortex in the Lithium-Pilocarpine Model of Status Epilepticus and the Role of Modulation of Endocannabinoid System.
Suleymanova, Elena M; Karan, Anna A; Borisova, Maria A; Volobueva, Maria N; Bolshakov, Alexey P.
Afiliación
  • Suleymanova EM; Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia.
  • Karan AA; Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia.
  • Borisova MA; Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia.
  • Volobueva MN; Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia.
  • Bolshakov AP; Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia.
Int J Mol Sci ; 24(7)2023 Mar 30.
Article en En | MEDLINE | ID: mdl-37047481
A significant body of evidence shows that neuroinflammation is one of the key processes in the development of brain pathology in trauma, neurodegenerative disorders, and epilepsy. Various brain insults, including severe and prolonged seizure activity during status epilepticus (SE), trigger proinflammatory cytokine release. We investigated the expression of the proinflammatory cytokines interleukin-1ß (Il1b) and interleukin-6 (Il6), and anti-inflammatory fractalkine (Cx3cl1) in the hippocampus, entorhinal cortex, and neocortex of rats 24 h, 7 days, and 5 months after lithium-pilocarpine SE. We studied the relationship between cytokine expression and neuronal death in the hippocampus and evaluated the effect of modulation of endocannabinoid receptors on neuroinflammation and neurodegeneration after SE. The results of the present study showed that inhibition of endocannabinoid CB1 receptors with AM251 early after SE had a transient neuroprotective effect that was absent in the chronic period and did not affect the development of spontaneous seizures after SE. At the same time, AM251 reduced the expression of Il6 in the chronic period after SE. Higher Cx3cl1 levels were found in rats with more prominent hippocampal neurodegeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Epiléptico / Neocórtex Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Epiléptico / Neocórtex Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza