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Evaluation of egg white hydrolysates on the hepatoprotective effect in vitro and in vivo.
Chen, Ya-Ting; Tu, Chao-Wen; Hou, Chih-Yao; Chen, Yu-An; Xu, Ruo-Qi; Kuo, Chia-Hung; Wu, Chih-Chung; Hsieh, Shu-Ling.
Afiliación
  • Chen YT; Department of Seafood Science, National Kaohsiung University of Science and Technology, 142 Haijhuan Rd., Nanzih District, Kaohsiung City, 81157 Taiwan, R.O.C.
  • Tu CW; Department of Seafood Science, National Kaohsiung University of Science and Technology, 142 Haijhuan Rd., Nanzih District, Kaohsiung City, 81157 Taiwan, R.O.C.
  • Hou CY; Department of Seafood Science, National Kaohsiung University of Science and Technology, 142 Haijhuan Rd., Nanzih District, Kaohsiung City, 81157 Taiwan, R.O.C.
  • Chen YA; Department of Seafood Science, National Kaohsiung University of Science and Technology, 142 Haijhuan Rd., Nanzih District, Kaohsiung City, 81157 Taiwan, R.O.C.
  • Xu RQ; Department of Seafood Science, National Kaohsiung University of Science and Technology, 142 Haijhuan Rd., Nanzih District, Kaohsiung City, 81157 Taiwan, R.O.C.
  • Kuo CH; Department of Seafood Science, National Kaohsiung University of Science and Technology, 142 Haijhuan Rd., Nanzih District, Kaohsiung City, 81157 Taiwan, R.O.C.
  • Wu CC; Department of Food and Nutrition, Providence University, Taichung, 43301 Taiwan.
  • Hsieh SL; Department of Seafood Science, National Kaohsiung University of Science and Technology, 142 Haijhuan Rd., Nanzih District, Kaohsiung City, 81157 Taiwan, R.O.C.
J Food Sci Technol ; 60(5): 1633-1641, 2023 May.
Article en En | MEDLINE | ID: mdl-37033317
The small molecule characteristics and nutritional value of egg white hydrolysates have been widely used. In the present study, in vitro and in vivo models were used to investigate the hepatoprotective effect of egg protein hydrolysate (EWH) by regulating the expression of antioxidant enzymes. The in vitro experiment results showed that 0.1, 0.5, and 1 mg/mL of EWH enhanced antioxidant activity in HepG2 cells by increased glutathione peroxidase (GPx) activity and reduced glutathione (GSH) levels. The in vivo experiment results showed that EWH (L) (38.5 mg/kg BW) and EWH (H) (385 mg/kg BW) alleviated carbon tetrachloride (CCl4)-induced hepatotoxicity in SD rats through reduced levels of serum aspartate aminotransferase (AST) alanine aminotransferase (ALT), and lipid peroxidation products malondialdehyde (MDA). In addition, EWH also ameliorates CCl4-induced hepatotoxicity in SD rats by increasing the antioxidant activity of GSH levels with a decrease in oxidized glutathione (GSSG) levels. Besides, EWH ameliorates liver tissue injuries by CCl4-induction. EWH has the highest glutamic acid in free amino acid composition, the second highest was aspartic acid, and the third was cystine, 204, 141, and 125 mg/100 g, respectively. These results suggest EWH has hepatoprotective potential through reduced lipid peroxidation products and enhanced antioxidant activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Food Sci Technol Año: 2023 Tipo del documento: Article Pais de publicación: India
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Food Sci Technol Año: 2023 Tipo del documento: Article Pais de publicación: India