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Maternal urinary vascular endothelial growth factor (VEGF) versus N.T. pro brain natriuretic peptide (NT-pro BNP) as novel biomarkers for placental accreta spectrum (PAS): A case-control study.
El Zohne, Randa A; Sobh, Ahmed A; Abd El-Rady, Nessren M; Radwan, Eman; AboTaleb, Hisham A; Youssef, Ahmed A; Yosef, Ali H; Ibrahim, Mostafa N; Badawy, Eman R.
Afiliación
  • El Zohne RA; Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Sobh AA; Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Abd El-Rady NM; Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Radwan E; Department of Medical Physiology, Sphinx University, New Assiut, Assiut, Egypt.
  • AboTaleb HA; Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Youssef AA; Department of Biochemistry, Sphinx University, New Assiut, Assiut, Egypt.
  • Yosef AH; Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Ibrahim MN; Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Badawy ER; Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Egypt J Immunol ; 30(2): 141-149, 2023 Apr.
Article en En | MEDLINE | ID: mdl-37031463
This study planned to compare the predictive ability of maternal urinary vascular endothelial growth factor (VEGF) versus N-terminal pro B-type natriuretic peptide (NT-pro BNP) for prediction of placenta accreta spectrum (PAS). This was a prospective case-control study carried out in a tertiary university hospital. It included pregnant women between 37-39 weeks. The study included 50 pregnant women classified in two groups. Group (Ι, n=25) were pregnant women with PAS, and group (II, n=25) women with uncomplicated pregnancies, as controls. Urine samples were collected, and quantitative analyses of VEGF and NT-pro BNP were performed by ELISA. VEGF was assessed with a cut point of 215.6 pg/ml and NT-pro BNP with a cut point of 182.2 pg/ml to predict the condition of PAS. Both biomarkers were good predictors of PAS with the area under the ROC curve (AUC) equal to (0.871 and 0.904), respectively. However, maternal urinary VEGF levels could predict PAS better than NT-pro BNP (OR=9.967, 95%CI 2.032-48.879, p=0.005) versus (OR=8.066, 95% CI 1.520 - 42.811, p=0.014) in NT-pro BNP. In conclusion, third trimester urinary levels of both VEGF and NT-pro BNP appear to be s crucially good predictors for PAS. However, VEGF is superior to NT-pro BNP in predicting women with PAS. These biomarkers present promising candidates as they can help to detect patients at high probability of PAS. They can be assessed by non-invasive, simple, and low-cost procedures.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptido Natriurético Encefálico / Factor A de Crecimiento Endotelial Vascular Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Egypt J Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Egipto
Buscar en Google
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Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptido Natriurético Encefálico / Factor A de Crecimiento Endotelial Vascular Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Egypt J Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Egipto