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Identifying breast cancer patients at risk of relapse despite pathological complete response after neoadjuvant therapy.
Huober, Jens; van Mackelenbergh, Marion; Schneeweiss, Andreas; Seither, Fenja; Blohmer, Jens-Uwe; Denkert, Carsten; Tesch, Hans; Hanusch, Claus; Salat, Christoph; Rhiem, Kerstin; Solbach, Christine; Fasching, Peter A; Jackisch, Christian; Reinisch, Mattea; Lederer, Bianca; Mehta, Keyur; Link, Theresa; Nekljudova, Valentina; Loibl, Sibylle; Untch, Michael.
Afiliación
  • Huober J; Universitätsfrauenklinik Ulm, Brustzentrum, Germany.
  • van Mackelenbergh M; Kantonsspital St.Gallen, Brustzentrum, Departement Interdisziplinäre medizinische Dienste, St. Gallen, Switzerland.
  • Schneeweiss A; Brustzentrum, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, 24105, Kiel, Germany. marion.vanmackelenbergh@gbg.de.
  • Seither F; Nationales Centrum für Tumorerkrankungen, Heidelberg, Germany.
  • Blohmer JU; German Breast Group, Neu-Isenburg, Germany.
  • Denkert C; Gynäkologie mit Brustzentrum, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Tesch H; Institut für Pathologie, Philipps-Universität Marburg, Marburg, Germany.
  • Hanusch C; Centrum für Hämatologie und Onkologie Bethanien Frankfurt, Frankfurt, Germany.
  • Salat C; Klinikum zum Roten Kreuz München, München, Germany.
  • Rhiem K; Hämatologisch-Onkologische Schwerpunktpraxis Salat/Stötzer, München, Germany.
  • Solbach C; Zentrum Familiärer Brust- und Eierstockkrebs, Uniklinik Köln, Germany.
  • Fasching PA; Universitätsklinikum Frankfurt, Frankfurt, Germany.
  • Jackisch C; Universitätsklinikum Erlangen, Erlangen, Germany.
  • Reinisch M; Sana Klinikum Offenbach, Offenbach, Germany.
  • Lederer B; Evang. Kliniken Essen-Mitte, Essen, Germany.
  • Mehta K; German Breast Group, Neu-Isenburg, Germany.
  • Link T; German Breast Group, Neu-Isenburg, Germany.
  • Nekljudova V; Department of Gynecology and Obstetrics, Technische Universität Dresden, Dresden, Germany.
  • Loibl S; German Breast Group, Neu-Isenburg, Germany.
  • Untch M; German Breast Group, Neu-Isenburg, Germany. sibylle.loibl@gbg.de.
NPJ Breast Cancer ; 9(1): 23, 2023 Apr 07.
Article en En | MEDLINE | ID: mdl-37029138
This retrospective pooled analysis aims to identify factors predicting relapse despite a pathologic complete response (pCR) in patients with breast cancer (BC). 2066 patients with a pCR from five neoadjuvant GBG/AGO-B trials fulfill the inclusion criteria of this analysis. Primary endpoint is disease-free survival (DFS); secondary endpoints is distant DFS (DDFS) and overall survival (OS). After a median follow-up of 57.6 months, DFS is significantly worse for patients with positive lymph nodes (cN+ vs cN0 hazard ratio [HR] 1.94, 95%CI 1.48-2.54; p < 0.001). In patients with triple-negative tumors, lobular histology (lobular vs other HR 3.55, 95%CI 1.53-8.23; p = 0.003), and clinical nodal involvement (cN+ vs cN0 HR 2.45, 95%CI 1.59-3.79; p < 0.001) predict a higher risk of DFS events. Patients with HER2-positive cT3/4 tumors have a significantly higher risk of relapse (cT3/4 vs cT1 HR 2.07, 95%CI 1.06-4.03; p = 0.033). Initial tumor load and histological type predict relapse in patients with a pCR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: NPJ Breast Cancer Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: NPJ Breast Cancer Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos