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Biological-Activity-Based Prioritization of Antidepressants in Wastewater in England and Japan.
Zhang, Han; Kato, Daisuke; Ihara, Mariko O; Jürgens, Monika D; Johnson, Andrew C; Chen, Jingwen; Tanaka, Hiroaki; Ihara, Masaru.
Afiliación
  • Zhang H; Research Center for Environmental Quality Management, Kyoto University, 1-2 Yumihama, Otsu, Shiga 520-0811, Japan.
  • Kato D; Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), Dalian Key Laboratory on Chemicals Risk Control and Pollution Prevention Technology, School of Environmental Science and Technology, Dalian University of Technology, Dalian, Liaoning 116024, China.
  • Ihara MO; Research Center for Environmental Quality Management, Kyoto University, 1-2 Yumihama, Otsu, Shiga 520-0811, Japan.
  • Jürgens MD; Research Center for Environmental Quality Management, Kyoto University, 1-2 Yumihama, Otsu, Shiga 520-0811, Japan.
  • Johnson AC; Centre for Ecology and Hydrology, Wallingford, Oxfordshire OX10 8BB, U.K.
  • Chen J; Centre for Ecology and Hydrology, Wallingford, Oxfordshire OX10 8BB, U.K.
  • Tanaka H; Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), Dalian Key Laboratory on Chemicals Risk Control and Pollution Prevention Technology, School of Environmental Science and Technology, Dalian University of Technology, Dalian, Liaoning 116024, China.
  • Ihara M; Research Center for Environmental Quality Management, Kyoto University, 1-2 Yumihama, Otsu, Shiga 520-0811, Japan.
Environ Sci Technol ; 57(16): 6444-6454, 2023 04 25.
Article en En | MEDLINE | ID: mdl-37022287
Antidepressants are one of the most commonly prescribed pharmaceuticals. Although they have been frequently detected in aquatic environments around the globe, little is known regarding their adverse effects on humans and aquatic organisms. Recently, an in vitro monoamine transporter inhibition assay was developed to detect transporter-inhibitory activities of antidepressants in wastewater in Japan. However, it was unclear which antidepressants were responsible for transporter-inhibitory activities in wastewater. Herein, the per capita consumption of 32 antidepressants, their excretion of unchanged parent compounds, per capita water consumption, removal rate during wastewater treatment processes, and potency values from the monoamine transporter inhibition assay were used to prioritize antidepressants of concern in effluent wastewater in England and Japan. In both countries, sertraline and O-desmethylvenlafaxine had the highest contribution to inhibitory activities against the human serotonin transporter (hSERT) and zebrafish SERT (zSERT), respectively. It was found that the antidepressants inhibited the zSERT more strongly than the hSERT. The inhibitory activities found against the zSERT in wastewater in England and Japan were higher than thresholds for abnormal behavior in fish. The antidepressants prioritized in this study provide insight into launching environmental monitoring and ecotoxicological studies of antidepressants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Aguas Residuales Tipo de estudio: Risk_factors_studies Límite: Animals / Humans País/Región como asunto: Asia / Europa Idioma: En Revista: Environ Sci Technol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Aguas Residuales Tipo de estudio: Risk_factors_studies Límite: Animals / Humans País/Región como asunto: Asia / Europa Idioma: En Revista: Environ Sci Technol Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos