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Paediatric actinomycosis: A 16-year, single-institution retrospective review of cases.
Chew, Siu-Jun; Low, Kelly Bb; Chong, Chia-Yin; Maiwald, Matthias; Thoon, Koh-Cheng; Ong, Rina Yl; Yung, Chee-Fu; Li, Jiahui; Nadua, Karen D; Kam, Kai-Qian; Tan, Henry Kk; Lian, Derrick Wq; Tan, Leon Yr; Tan, Natalie Wh.
Afiliación
  • Chew SJ; Department of Pediatric Medicine, KK Women's and Children's Hospital, Singapore.
  • Low KB; Department of Pediatric Medicine, KK Women's and Children's Hospital, Singapore.
  • Chong CY; Infectious Disease Service, Department of Pediatric Medicine, KK Women's and Children's Hospital, Singapore.
  • Maiwald M; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Thoon KC; Duke-National University of Singapore Medical School, Singapore.
  • Ong RY; Lee Kong Chian School of Medicine, Imperial College London, Nanyang Technological University, Singapore.
  • Yung CF; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Li J; Duke-National University of Singapore Medical School, Singapore.
  • Nadua KD; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.
  • Kam KQ; Infectious Disease Service, Department of Pediatric Medicine, KK Women's and Children's Hospital, Singapore.
  • Tan HK; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Lian DW; Duke-National University of Singapore Medical School, Singapore.
  • Tan LY; Lee Kong Chian School of Medicine, Imperial College London, Nanyang Technological University, Singapore.
  • Tan NW; Department of Pharmacy, KK Women's and Children's Hospital, Singapore.
J Paediatr Child Health ; 59(6): 833-839, 2023 06.
Article en En | MEDLINE | ID: mdl-37017147
AIM: Actinomycosis is a rare subacute to chronic granulomatous infection which can mimic other infectious or malignant diseases. This study examined the epidemiology and treatment outcome of actinomycosis in children. METHODS: A retrospective study on children admitted for actinomycosis in a tertiary paediatric hospital in Singapore, from January 2004 to December 2020. Clinical profile, therapeutic interventions and outcomes were examined. RESULTS: A total of 10 patients were identified; 7 were female. The median age at first presentation was 9.8 years (range 4.7-15.7). The most common presenting symptom was fever (n = 6, 60%), followed by facial or neck swelling (n = 3, 30%) and ear pain (n = 3, 30%). Actinomycosis occurred predominantly in the orocervicofacial region (n = 6, 60%). Four patients (40%) had preceding dental infections in the form of dental caries or gingivitis. One patient had poorly controlled insulin-dependent diabetes mellitus. Actinomycosis was confirmed via culture in four patients, histopathology in four patients and both methods in two patients. All except one patient (n = 9, 90%) underwent surgical procedures. All patients received ampicillin or amoxicillin/clavulanate or other beta-lactams, for a median duration of 6.5 months (range 1.5-14). Complications included osteomyelitis (n = 4, 40%), mastoiditis (n = 2, 20%), brain abscess (n = 1, 10%) and recurrent neck abscess (n = 1, 10%). There was no mortality and all patients achieved complete resolution. CONCLUSIONS: Paediatric actinomycosis was rare in our 16-year review, but had a high complication rate. It can occur in immunocompetent patients, and dental infection was the predominant risk factor identified. Prognosis was excellent after surgical intervention and appropriate antimicrobial therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actinomicosis / Caries Dental Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Paediatr Child Health Asunto de la revista: PEDIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actinomicosis / Caries Dental Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Paediatr Child Health Asunto de la revista: PEDIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Australia