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Individual and environmental determinants of serum ferritin levels: A structural equation model.
Vinkenoog, Marieke; de Groot, Rosa; Lakerveld, Jeroen; Janssen, Mart; van den Hurk, Katja.
Afiliación
  • Vinkenoog M; Transfusion Technology Assessment, Department of Donor Medicine Research, Sanquin Research, Amsterdam, The Netherlands.
  • de Groot R; Leiden Institute of Advanced Computer Science, Leiden University, Leiden, The Netherlands.
  • Lakerveld J; Donor Studies, Department of Donor Medicine Research, Sanquin Research, Amsterdam, The Netherlands.
  • Janssen M; Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
  • van den Hurk K; Upstream Team, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
Transfus Med ; 33(2): 113-122, 2023 Apr.
Article en En | MEDLINE | ID: mdl-37009681
BACKGROUND AND OBJECTIVES: Serum ferritin levels are increasingly being used to assess iron stores. Considerable variation in ferritin levels within and between individuals has been observed, but our current understanding of factors that explain this variation is far from complete. We aim to combine multiple potential determinants in an integrative model, and investigate their relative importance and potential interactions. METHODS: We use ferritin measurements collected by Sanquin Blood Bank on both prospective (N = 59 596) and active blood donors (N = 78 318) to fit a structural equation model with three latent constructs (individual characteristics, donation history, and environmental factors). Parameters were estimated separately by sex and donor status. RESULTS: The model explained 25% of ferritin variance in prospective donors, and 40% in active donors. Individual characteristics and donation history were the most important determinants of ferritin levels in active donors. The association between environmental factors and ferritin was smaller but still substantial; higher exposure to air pollution was associated with higher ferritin levels, and this association was considerably stronger for active blood donors than for prospective donors. DISCUSSION: In active donors, individual characteristics explain 20% (17%) of ferritin variation, donation history explains 14% (25%) and environmental factors explain 5% (4%) for women (men). Our model presents known ferritin determinants in a broader perspective, allowing for comparison with other determinants as well as between new and active donors, or between men and women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ferritinas / Hierro Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Transfus Med Asunto de la revista: HEMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ferritinas / Hierro Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Transfus Med Asunto de la revista: HEMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido