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Salmonella enhances osteogenic differentiation in adipose-derived mesenchymal stem cells.
Mohamad-Fauzi, Nuradilla; Shaw, Claire; Foutouhi, Soraya H; Hess, Matthias; Kong, Nguyet; Kol, Amir; Storey, Dylan Bobby; Desai, Prerak T; Shah, Jigna; Borjesson, Dori; Murray, James D; Weimer, Bart C.
Afiliación
  • Mohamad-Fauzi N; Department of Animal Science, College of Agricultural and Environmental Sciences, University of California, Davis, Davis, CA, United States.
  • Shaw C; Department of Animal Science, College of Agricultural and Environmental Sciences, University of California, Davis, Davis, CA, United States.
  • Foutouhi SH; Department of Population Health and Reproduction, 100K Pathogen Genome Project, Davis, CA, United States.
  • Hess M; Department of Animal Science, College of Agricultural and Environmental Sciences, University of California, Davis, Davis, CA, United States.
  • Kong N; Department of Population Health and Reproduction, 100K Pathogen Genome Project, Davis, CA, United States.
  • Kol A; Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA, United States.
  • Storey DB; Department of Population Health and Reproduction, 100K Pathogen Genome Project, Davis, CA, United States.
  • Desai PT; Department of Population Health and Reproduction, 100K Pathogen Genome Project, Davis, CA, United States.
  • Shah J; Department of Population Health and Reproduction, 100K Pathogen Genome Project, Davis, CA, United States.
  • Borjesson D; Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA, United States.
  • Murray JD; Department of Animal Science, College of Agricultural and Environmental Sciences, University of California, Davis, Davis, CA, United States.
  • Weimer BC; Department of Population Health and Reproduction, 100K Pathogen Genome Project, Davis, CA, United States.
Front Cell Dev Biol ; 11: 1077350, 2023.
Article en En | MEDLINE | ID: mdl-37009487
The potential of mesenchymal stem cells (MSCs) for tissue repair and regeneration has garnered great attention. While MSCs are likely to interact with microbes at sites of tissue damage and inflammation, like in the gastrointestinal system, the consequences of pathogenic association on MSC activities have yet to be elucidated. This study investigated the effects of pathogenic interaction on MSC trilineage differentiation paths and mechanisms using model intracellular pathogen Salmonella enterica ssp enterica serotype Typhimurium. The examination of key markers of differentiation, apoptosis, and immunomodulation demonstrated that Salmonella altered osteogenic and chondrogenic differentiation pathways in human and goat adipose-derived MSCs. Anti-apoptotic and pro-proliferative responses were also significantly upregulated (p < 0.05) in MSCs during Salmonella challenge. These results together indicate that Salmonella, and potentially other pathogenic bacteria, can induce pathways that influence both apoptotic response and functional differentiation trajectories in MSCs, highlighting that microbes have a potentially significant role as influencers of MSC physiology and immune activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza