The inhibitory and inducing effects of ritonavir on hepatic and intestinal CYP3A and other drug-handling proteins.

Loos, Nancy H C; Beijnen, Jos H; Schinkel, Alfred H

Loos, Nancy H C; Beijnen, Jos H; Schinkel, Alfred H.

Afiliación

Loos NHC; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands.
Beijnen JH; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology, Universiteitsweg 99, 3584 CG, Utrecht, the Netherlands; The Netherlands Cancer Institute, Division of Pharmacy and Pharmacology, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands.
Schinkel AH; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands. Electronic address: a.schinkel@nki.nl.

Biomed Pharmacother ; 162: 114636, 2023 Jun.

Article en En | MEDLINE | ID: mdl-37004323

Asunto(s)

COVID-19; Inhibidores de la Proteasa del VIH; Humanos; Ritonavir/farmacología; Citocromo P-450 CYP3A/metabolismo; Preparaciones Farmacéuticas; Tratamiento Farmacológico de COVID-19; Sistema Enzimático del Citocromo P-450/metabolismo; Interacciones Farmacológicas

Palabras clave

CYP3A; Induction; Inhibition; P-glycoprotein; Ritonavir

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de la Proteasa del VIH / COVID-19 Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Francia

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