Your browser doesn't support javascript.
loading
Relating CYP2B6 genotype and efavirenz resistance among post-partum women living with HIV with high viremia in Uganda: a nested cross-sectional study.
Buzibye, Allan; Wools-Kaloustian, Kara; Olagunju, Adeniyi; Twinomuhwezi, Ellon; Yiannoutsos, Constantin; Owen, Andrew; Neary, Megan; Matovu, Joshua; Banturaki, Grace; Castelnuovo, Barbara; Lamorde, Mohammed; Khoo, Saye; Waitt, Catriona; Kiragga, Agnes.
Afiliación
  • Buzibye A; Research Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, P. O. Box 22418, Kampala, Uganda. abuzibye@idi.co.ug.
  • Wools-Kaloustian K; School of Medicine, Infectious Diseases, Indiana University, Indianapolis, IN, USA.
  • Olagunju A; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.
  • Twinomuhwezi E; Research Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, P. O. Box 22418, Kampala, Uganda.
  • Yiannoutsos C; Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
  • Owen A; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.
  • Neary M; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.
  • Matovu J; Research Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, P. O. Box 22418, Kampala, Uganda.
  • Banturaki G; Research Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, P. O. Box 22418, Kampala, Uganda.
  • Castelnuovo B; Research Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, P. O. Box 22418, Kampala, Uganda.
  • Lamorde M; Research Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, P. O. Box 22418, Kampala, Uganda.
  • Khoo S; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.
  • Waitt C; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.
  • Kiragga A; Research Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, P. O. Box 22418, Kampala, Uganda.
AIDS Res Ther ; 20(1): 20, 2023 03 31.
Article en En | MEDLINE | ID: mdl-37004096
BACKGROUND: We investigated the association between CYP2B6 polymorphisms and efavirenz drug resistance among women living with HIV who started on antiretroviral therapy during pregnancy and with high viremia during post-partum. METHODS: This was a cross-sectional study of women with viral loads greater than 1000 copies/ml who were at least 6 weeks postpartum. Sanger sequencing was used to detect resistant mutations, as well as host genotyping, and efavirenz resistance was compared among the metabolizer genotypes. RESULTS: Over the course of one year (July 2017-July 2018), 322 women were screened, with 110 (34.2%) having viral loads of 1000 copies/ml and 62 having whole blood available for genotyping. Fifty-nine of these women had both viral resistance and human host genotypic results. Efavirenz resistance according to metabolizer genotype was; 47% in slow, 34% in extensive and 28% in intermediate metabolizers, but the difference was not statistically significant due to the small sample size. CONCLUSIONS: There was no statistically significant difference in EFV resistance between EFV metabolizer genotypes in women who started antiretroviral therapy during pregnancy and had high viremia in the postpartum period. However, a numerical trend was discovered, which calls for confirmation in a large, well-designed, statistically powered study.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Fármacos Anti-VIH Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy País/Región como asunto: Africa Idioma: En Revista: AIDS Res Ther Año: 2023 Tipo del documento: Article País de afiliación: Uganda Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Fármacos Anti-VIH Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy País/Región como asunto: Africa Idioma: En Revista: AIDS Res Ther Año: 2023 Tipo del documento: Article País de afiliación: Uganda Pais de publicación: Reino Unido