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Cerebral abscesses with odontogenic origin: a population-based cohort study.
Jespersen, Frederik V B; Hansen, Signe U-B; Jensen, Simon S; Omland, Lars H; Helweg-Larsen, Jannik; Bjarnsholt, Thomas; Nielsen, Claus H; Ziebell, Morten; Bodilsen, Jacob; Markvart, Merete.
Afiliación
  • Jespersen FVB; Cariology and Endodontics, Section of Clinical Oral Microbiology, Department of Odontology, University of Copenhagen, Nørre Allé 20, 2200, Copenhagen, Denmark.
  • Hansen SU; Department of Oral & Maxillofacial Surgery, Copenhagen University Hospital, Copenhagen, Denmark.
  • Jensen SS; Cariology and Endodontics, Section of Clinical Oral Microbiology, Department of Odontology, University of Copenhagen, Nørre Allé 20, 2200, Copenhagen, Denmark.
  • Omland LH; Cariology and Endodontics, Section of Clinical Oral Microbiology, Department of Odontology, University of Copenhagen, Nørre Allé 20, 2200, Copenhagen, Denmark.
  • Helweg-Larsen J; Department of Oral & Maxillofacial Surgery, Copenhagen University Hospital, Copenhagen, Denmark.
  • Bjarnsholt T; Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark.
  • Nielsen CH; Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark.
  • Ziebell M; Department of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Bodilsen J; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
  • Markvart M; Cariology and Endodontics, Section of Clinical Oral Microbiology, Department of Odontology, University of Copenhagen, Nørre Allé 20, 2200, Copenhagen, Denmark.
Clin Oral Investig ; 27(7): 3639-3648, 2023 Jul.
Article en En | MEDLINE | ID: mdl-37002439
OBJECTIVES: Recent studies have indicated that cerebral abscess (CA) patients with odontogenic origin are on the rise. However, CA patients are often poorly characterized and with an unknown etiologic background. The purpose of this study is to identify and characterize CA patients that may have an odontogenic origin based on microbiologic, radiographic, and/or clinical findings. MATERIALS AND METHODS: This is a population-based cohort study analyzing retrospective and prospective data from CA patients. Radiographic examinations of panoramic radiographs (PRs) or computed tomography (CT) scans were conducted. CA patients characterized with odontogenic origin required the fulfilment of the following criteria on admission: (1) Oral pathologic conditions were the only bacterial infections present, (2) oral microorganisms were isolated in the purulent exudate from the brain, and (3) radiographically and/or clinical recordings of oral pathologic conditions. RESULTS: A total of 44 patients could be included in this study of which 25 (57%) were characterized as having CA with a likely odontogenic origin. Type two diabetes (T2D) (p = 0.014) and microorganisms of the Streptococcus anginosus group (SAG) (p < 0.01) were overrepresented in patients with CAs of odontogenic origin. CONCLUSIONS: Odontogenic infections may cause CAs to a greater extent than previously assumed. T2D was overrepresented among patients with odontogenic CA. When microorganisms of the SAG were isolated from the brain pus, CA patients had a predisposing odontogenic or sinus infection. CLINICAL RELEVANCE: The identification of patients with a likely odontogenic CA will contribute to understanding the etiology of the infectious disease and highlighting the importance of preserving oral health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Absceso Encefálico / Diabetes Mellitus Tipo 2 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Oral Investig Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Absceso Encefálico / Diabetes Mellitus Tipo 2 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Oral Investig Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Alemania