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Attack phenotypes and disease course in pediatric MOGAD.
Santoro, Jonathan D; Beukelman, Timothy; Hemingway, Cheryl; Hokkanen, Suvi R K; Tennigkeit, Frank; Chitnis, Tanuja.
Afiliación
  • Santoro JD; Division of Neuroimmunology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California, USA.
  • Beukelman T; Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
  • Hemingway C; Epi Excellence LLC, Garnet Valley, Pennsylvania, USA.
  • Hokkanen SRK; Great Ormond Street Hospital for Children, London, UK.
  • Tennigkeit F; UCB Pharma, Brussels, Belgium.
  • Chitnis T; UCB Biosciences, Monheim, Germany.
Ann Clin Transl Neurol ; 10(5): 672-685, 2023 05.
Article en En | MEDLINE | ID: mdl-37000895
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune demyelinating condition that affects children differently than adults. We performed a literature review to assess the presentation and clinical course of pediatric MOGAD. The most common initial phenotype is acute disseminated encephalomyelitis, especially among children younger than five years, followed by optic neuritis (ON) and/or transverse myelitis. Approximately one-quarter of children with MOGAD have at least one relapse that typically occurs within three years of disease onset and often includes ON, even if ON was not present at onset. Clinical risk factors for a relapsing course have not been elucidated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Neuritis Óptica Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Ann Clin Transl Neurol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Neuritis Óptica Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Ann Clin Transl Neurol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos