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Platelet function in neonates and children.
Van Den Helm, Suelyn; McCafferty, Conor; Letunica, Natasha; Chau, Ka Ying; Monagle, Paul; Ignjatovic, Vera.
Afiliación
  • Van Den Helm S; Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
  • McCafferty C; Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
  • Letunica N; Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia.
  • Chau KY; Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia.
  • Monagle P; Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Department of Clinical Haematology, The Royal Children's Hospital, Melbourne, Australia; Kids Cancer Centre, Sydney Children's Hospital, Ra
  • Ignjatovic V; Haematology Research, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Johns Hopkins All Children's Hospital, St Petersburg, USA. Electronic address: vignjat1@jhmi.edu.
Thromb Res ; 231: 236-246, 2023 11.
Article en En | MEDLINE | ID: mdl-36997443
Platelets are major regulators of haemostasis and coagulation. The primary role of platelets in coagulation is to form a stable clot and stop bleeding. Studies of platelet phenotype and function in neonates and children have been restricted by the large volumes required for many common platelet function tests such as platelet aggregometry. Developmental changes in platelets have not been as well described as developmental changes in plasma coagulation proteins, and overall, platelet phenotype and function in neonates and children has been understudied when compared to adults. Recent developments in more sensitive platelet function testing methods requiring smaller blood volumes such as flow cytometry has enabled recent studies to further investigate platelet phenotype and function in neonates and children. In this review we will provide an overview of recent advances from the past five years in platelets in the context of developmental haemostasis, as well as the role of platelets in neonatal paediatric disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaquetas / Agregación Plaquetaria Límite: Adult / Child / Humans / Newborn Idioma: En Revista: Thromb Res Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaquetas / Agregación Plaquetaria Límite: Adult / Child / Humans / Newborn Idioma: En Revista: Thromb Res Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos