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mRNA challenge predicts brain cancer immunogenicity and response to checkpoint inhibitors.
Castillo, Paul; Ogando-Rivas, Elizabeth; Geffrard, Hilary; Pepe, Alfonso; Liu, Ruixuan; Nguyen, Duy T; Pedro, Diego I; Zhang, Dingpeng; DeVries, Anna; Qdaisat, Sadeem; Karachi, Aida; Rahman, Maryam; Weidert, Frances; Milner, Rowan; Huang, Jianping; Silver, Natalie L; Ligon, John; Li, Derek; Lee, Ji-Hyun; Carrera-Justiz, Sheila; Mitchell, Duane A; Mendez-Gomez, Hector; Sawyer, W Gregory; Sayour, Elias J.
bioRxiv ; 2023 Mar 23.
Article en En | MEDLINE | ID: mdl-36993158
To prospectively determine whether brain tumors will respond to immune checkpoint inhibitors (ICIs), we developed a novel mRNA vaccine as a viral mimic to elucidate cytokine release from brain cancer cells in vitro. Our results indicate that cytokine signatures following mRNA challenge differ substantially from ICI responsive versus non-responsive murine tumors. These findings allow for creation of a diagnostic assay to quickly assess brain tumor immunogenicity, allowing for informed treatment with ICI or lack thereof in poorly immunogenic settings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos