Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase.

Ge, Weiran; Yu, Cong; Li, Jingjing; Yu, Zhenyu; Li, Xiaorong; Zhang, Yan; Liu, Chao-Pei; Li, Yingfeng; Tian, Changlin; Zhang, Xinzheng; Li, Guohong; Zhu, Bing; Xu, Rui-Ming

Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase.

Ge, Weiran; Yu, Cong; Li, Jingjing; Yu, Zhenyu; Li, Xiaorong; Zhang, Yan; Liu, Chao-Pei; Li, Yingfeng; Tian, Changlin; Zhang, Xinzheng; Li, Guohong; Zhu, Bing; Xu, Rui-Ming.

Afiliación

Ge W; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Yu C; School of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Li J; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Yu Z; School of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Li X; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Zhang Y; School of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Liu CP; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Li Y; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Tian C; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Zhang X; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Li G; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Zhu B; Division of Life Sciences and Anhui Provisional Engineering Laboratory of Peptide Drugs, University of Science and Technology of China, Hefei, China.
Xu RM; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Nature ; 616(7955): 176-182, 2023 04.

Article en En | MEDLINE | ID: mdl-36991118

Asunto(s)

Enzimas Desubicuitinizantes; Histonas; Complejo Represivo Polycomb 1; Proteínas del Grupo Polycomb; Humanos; Microscopía por Crioelectrón; Histonas/química; Histonas/metabolismo; Nucleosomas/química; Nucleosomas/genética; Nucleosomas/metabolismo; Complejo Represivo Polycomb 1/química; Complejo Represivo Polycomb 1/metabolismo; Complejo Represivo Polycomb 1/ultraestructura; Proteínas del Grupo Polycomb/química; Proteínas del Grupo Polycomb/metabolismo; Proteínas del Grupo Polycomb/ultraestructura; Ubiquitina/metabolismo; Ubiquitina Tiolesterasa/química; Ubiquitina Tiolesterasa/metabolismo; Ubiquitina Tiolesterasa/ultraestructura; Ubiquitinación; Proteínas Represoras/química; Proteínas Represoras/metabolismo; Proteínas Represoras/ultraestructura; Dominio Catalítico; Enzimas Desubicuitinizantes/clasificación; Enzimas Desubicuitinizantes/metabolismo; Enzimas Desubicuitinizantes/ultraestructura; Especificidad por Sustrato; Ubiquitina-Proteína Ligasas/química; Ubiquitina-Proteína Ligasas/metabolismo; Ubiquitina-Proteína Ligasas/ultraestructura

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histonas / Proteínas del Grupo Polycomb / Complejo Represivo Polycomb 1 / Enzimas Desubicuitinizantes Límite: Humans Idioma: En Revista: Nature Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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