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Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case-Control Study Based on the Beijing Birth Cohort Study (BBCS) in China.
Han, Weiling; Zheng, Wei; Wang, Aili; Chen, Junxi; Wang, Jia; Huang, Junhua; An, Hang; Ma, Yuru; Zhang, Kexin; Yang, Ruihua; Yan, Lailai; Li, Zhiwen; Li, Guanghui.
Afiliación
  • Han W; Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
  • Zheng W; Beijing Maternal and Child Health Care Hospital, Beijing 100026, China.
  • Wang A; Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
  • Chen J; Beijing Maternal and Child Health Care Hospital, Beijing 100026, China.
  • Wang J; Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
  • Huang J; Beijing Maternal and Child Health Care Hospital, Beijing 100026, China.
  • An H; Department of Obstetrics, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China.
  • Ma Y; Institute of Reproductive and Child Health, Peking University, Beijing 100191, China.
  • Zhang K; Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, China.
  • Yang R; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
  • Yan L; Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
  • Li Z; Beijing Maternal and Child Health Care Hospital, Beijing 100026, China.
  • Li G; Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Nutrients ; 15(6)2023 Mar 15.
Article en En | MEDLINE | ID: mdl-36986144
We performed this study to clarify the dynamic changes in maternal manganese (Mn) concentration during pregnancy and its association with spontaneous preterm birth (SPB). A nested case-control study was conducted based on the Beijing Birth Cohort Study (BBCS) from 2018 to 2020. Singleton pregnancy women aged 18-44 (n = 488) were involved in the study, including 244 cases of SPB and 244 controls. All of the participants provided blood samples twice (in their first and third trimesters). Inductively coupled plasma mass spectrometry (ICP-MS) was used for the laboratory analysis, and unconditional logistic regression was used for the statistical analysis. We found that the maternal Mn levels were significantly higher in the third trimester than those in the first trimester (median: 1.23 vs. 0.81 ng/mL). The SPB risk was increased to 1.65 (95% CI: 1.04-2.62, p = 0.035) in the highest Mn level (third tertile) in the third trimester, especially in normal-weight women (OR: 2.07, 95% CI: 1.18-3.61, p = 0.011) or non-premature rupture of membrane (PROM) women (OR: 3.93, 95% CI: 2.00-7.74, p < 0.001). Moreover, a dose-dependent relationship exists between the SPB risk and maternal Mn concentration in non-PROM women (P trend < 0.001). In conclusion, dynamic monitoring of maternal Mn level during pregnancy would be helpful for SPB prevention, especially in normal-weight and non-PROM women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nacimiento Prematuro / Manganeso Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Nutrients Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nacimiento Prematuro / Manganeso Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Nutrients Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza