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New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins.
Khomenko, Tatyana M; Shtro, Anna A; Galochkina, Anastasia V; Nikolaeva, Yulia V; Garshinina, Anzhelika V; Borisevich, Sophia S; Korchagina, Dina V; Volcho, Konstantin P; Salakhutdinov, Nariman F.
Afiliación
  • Khomenko TM; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia.
  • Shtro AA; Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, 197376 Saint-Petersburg, Russia.
  • Galochkina AV; Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, 197376 Saint-Petersburg, Russia.
  • Nikolaeva YV; Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, 197376 Saint-Petersburg, Russia.
  • Garshinina AV; Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, 197376 Saint-Petersburg, Russia.
  • Borisevich SS; Laboratory of Physical Chemistry, Ufa Chemistry Institute of the Ufa Federal Research Center, 71 Octyabrya pr., 450054 Ufa, Russia.
  • Korchagina DV; Institute of Cyber Intelligence Systems, National Research Nuclear University MEPhI, 115409 Moscow, Russia.
  • Volcho KP; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia.
  • Salakhutdinov NF; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia.
Molecules ; 28(6)2023 Mar 15.
Article en En | MEDLINE | ID: mdl-36985645
Respiratory syncytial virus (RSV) causes annual epidemics of respiratory infection. Usually harmless to adults, the RSV infection can be dangerous to children under 3 years of age and elderly people over 65 years of age, often causing serious problems, even death. At present, there are no vaccines and specific chemotherapeutic agents for the treatment of this disease, so the search for low-molecular weight compounds to combat RSV is a challenge. In this work, we have shown, for the first time, that monoterpene-substituted arylcoumarins are efficient RSV replication inhibitors at low micromolar concentrations. The most active compound has a selectivity index of about 200 and acts most effectively at the early stages of infection. The F protein of RSV is a potential target for these compounds, which is also confirmed by molecular docking and molecular dynamics simulation data.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio Límite: Aged / Child / Child, preschool / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio Límite: Aged / Child / Child, preschool / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza