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Relapse of Monoclonal Gammopathy of Renal Significance after mRNA COVID-19 Vaccination: A Case Report.
Tsaftaridis, Nikolaos; Potoupni, Victoria; Koraka, Lydia; Iatridi, Fotini; Lioulios, Georgios; Christodoulou, Michalis; Moysidou, Eleni; Stai, Stamatia; Fylaktou, Asimina; Papagianni, Aikaterini; Stangou, Maria.
Afiliación
  • Tsaftaridis N; School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
  • Potoupni V; School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
  • Koraka L; School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
  • Iatridi F; Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, 54642 Thessaloniki, Greece.
  • Lioulios G; Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, 54642 Thessaloniki, Greece.
  • Christodoulou M; Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, 54642 Thessaloniki, Greece.
  • Moysidou E; Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, 54642 Thessaloniki, Greece.
  • Stai S; Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, 54642 Thessaloniki, Greece.
  • Fylaktou A; National Peripheral Histocompatibility Center, Department of Immunology, Hippokration Hospital, 54642 Thessaloniki, Greece.
  • Papagianni A; Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, 54642 Thessaloniki, Greece.
  • Stangou M; Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, 54642 Thessaloniki, Greece.
Life (Basel) ; 13(3)2023 Mar 09.
Article en En | MEDLINE | ID: mdl-36983889
This case report represents the first suspected case of light chain deposition disease relapse associated with mRNA COVID-19 vaccination. The 75-year-old female patient of Greek ethnicity was admitted to the clinic for the investigation of worsening renal function detected on routine lab examinations, two weeks after she received the second dose of the Moderna COVID-19 vaccine (mRNA-1273). Rapidly progressive glomerulonephritis and anemia were the most notable findings. She had a history of LCDD, which had remained stable for four years. Serum protein immunofixation showed monoclonal kappa zones, and a bone marrow biopsy revealed 5% plasma cell infiltration. These, along with other investigations, established the diagnosis of LCDD recurrence. The patient was started on chemotherapy, which improved her immunological profile, but not her renal function. The patient has remained on hemodialysis since. The association between mRNA vaccinations and LCDD relapse may be grounds for investigations into the pathophysiology of MGRS, given the patient's previous long-term remission. This case report is not intended to directly inform changes in clinical practice. We must stress the importance of following all standardized vaccination protocols, especially in immunocompromised patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Life (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Life (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza