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Dermatophagoides farinae Extract Induces Interleukin 33-Mediated Atopic Skin Inflammation via Activation of RIP1.
Jin, Meiling; Bang, Jin Seon; Ha, Dae-Lyong; Kim, Jun Young; Park, Kyung Duck; Lee, Weon Ju; Lee, Seok-Jong; Choi, Jin Kyeong; Choi, Young-Ae; Jang, Yong Hyun; Kim, Sang-Hyun.
Afiliación
  • Jin M; Department of Pharmacology, School of Medicine, Yanbian National University, Yanji 133002, China.
  • Bang JS; Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
  • Ha DL; Department of Dermatology, School of Medicine, Bio-Medical Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea.
  • Kim JY; Department of Dermatology, School of Medicine, Bio-Medical Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea.
  • Park KD; Department of Dermatology, School of Medicine, Bio-Medical Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea.
  • Lee WJ; Department of Dermatology, School of Medicine, Bio-Medical Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea.
  • Lee SJ; Department of Dermatology, School of Medicine, Bio-Medical Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea.
  • Choi JK; Department of Dermatology, School of Medicine, Bio-Medical Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea.
  • Choi YA; Department of Immunology, Jeonbuk National University Medical School, Jeonju 54907, Republic of Korea.
  • Jang YH; Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
  • Kim SH; Department of Dermatology, School of Medicine, Bio-Medical Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea.
Int J Mol Sci ; 24(6)2023 Mar 09.
Article en En | MEDLINE | ID: mdl-36982304
Receptor-interacting protein kinase (RIP) family 1 signaling has complex effects on inflammatory processes and cell death, but little is known concerning allergic skin diseases. We examined the role of RIP1 in Dermatophagoides farinae extract (DFE)-induced atopic dermatitis (AD)-like skin inflammation. RIP1 phosphorylation was increased in HKCs treated with DFE. Nectostatin-1, a selective and potent allosteric inhibitor of RIP1, inhibited AD-like skin inflammation and the expression of histamine, total IgE, DFE-specific IgE, IL-4, IL-5, and IL-13 in an AD-like mouse model. The expression of RIP1 was increased in ear skin tissue from a DFE-induced mouse model with AD-like skin lesions and in the lesional skin of AD patients with high house dust mite sensitization. The expression of IL-33 was down-regulated after RIP1 inhibition, and the levels of IL-33 were increased by over-expression of RIP1 in keratinocytes stimulated with DFE. Nectostatin-1 reduced IL-33 expression in vitro and in the DFE-induced mouse model. These results suggest that RIP1 can be one of the mediators that regulate IL-33-mediated atopic skin inflammation by house dust mites.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dermatitis Atópica Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dermatitis Atópica Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza