Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts.

Choi, Seung-Il; Lee, Ga-Hyun; Woo, Jong-Hwan; Jun, Ikhyun; Kim, Eung Kweon

Choi, Seung-Il; Lee, Ga-Hyun; Woo, Jong-Hwan; Jun, Ikhyun; Kim, Eung Kweon.

Afiliación

Choi SI; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Lee GH; Department of Food Marketing and Safety, Konkuk University, Seoul 05029, Republic of Korea.
Woo JH; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Jun I; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Kim EK; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

Genes (Basel) ; 14(3)2023 02 24.

Article en En | MEDLINE | ID: mdl-36980838

Asunto(s)

Distrofias Hereditarias de la Córnea; GTP Fosfohidrolasas; Humanos; Apoptosis/genética; Distrofias Hereditarias de la Córnea/genética; Fibroblastos/metabolismo; GTP Fosfohidrolasas/genética; GTP Fosfohidrolasas/metabolismo; Mitocondrias/genética; Mitocondrias/metabolismo

Palabras clave

NRF1; OPA1; PGC1α; corneal fibroblasts; fission and fusion; granular corneal dystrophy type 2; mitochondria

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Distrofias Hereditarias de la Córnea / GTP Fosfohidrolasas Límite: Humans Idioma: En Revista: Genes (Basel) Año: 2023 Tipo del documento: Article Pais de publicación: Suiza

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