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Dysregulation of Serum MicroRNA after Intracerebral Hemorrhage in Aged Mice.
Robles, Dominic; Guo, De-Huang; Watson, Noah; Asante, Diana; Sukumari-Ramesh, Sangeetha.
Afiliación
  • Robles D; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, CB3618, 30912 Augusta, Georgia.
  • Guo DH; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, CB3618, 30912 Augusta, Georgia.
  • Watson N; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, CB3618, 30912 Augusta, Georgia.
  • Asante D; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, CB3618, 30912 Augusta, Georgia.
  • Sukumari-Ramesh S; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, CB3618, 30912 Augusta, Georgia.
Biomedicines ; 11(3)2023 Mar 08.
Article en En | MEDLINE | ID: mdl-36979801
Stroke is one of the most common diseases that leads to brain injury and mortality in patients, and intracerebral hemorrhage (ICH) is the most devastating subtype of stroke. Though the prevalence of ICH increases with aging, the effect of aging on the pathophysiology of ICH remains largely understudied. Moreover, there is no effective treatment for ICH. Recent studies have demonstrated the potential of circulating microRNAs as non-invasive diagnostic and prognostic biomarkers in various pathological conditions. While many studies have identified microRNAs that play roles in the pathophysiology of brain injury, few demonstrated their functions and roles after ICH. Given this significant knowledge gap, the present study aims to identify microRNAs that could serve as potential biomarkers of ICH in the elderly. To this end, sham or ICH was induced in aged C57BL/6 mice (18-24 months), and 24 h post-ICH, serum microRNAs were isolated, and expressions were analyzed. We identified 28 significantly dysregulated microRNAs between ICH and sham groups, suggesting their potential to serve as blood biomarkers of acute ICH. Among those microRNAs, based on the current literature, miR-124-3p, miR-137-5p, miR-138-5p, miR-219a-2-3p, miR-135a-5p, miR-541-5p, and miR-770-3p may serve as the most promising blood biomarker candidates of ICH, warranting further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Suiza