Your browser doesn't support javascript.
loading
Electrochemical Sensing of Urinary Chloride Ion Concentration for Near Real-Time Monitoring.
Nelson, Anna M; Habibi, Sanaz; DeLancey, John O L; Ashton-Miller, James A; Burns, Mark A.
Afiliación
  • Nelson AM; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
  • Habibi S; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
  • DeLancey JOL; Department of Obstetrics & Gynecology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Ashton-Miller JA; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
  • Burns MA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Biosensors (Basel) ; 13(3)2023 Feb 28.
Article en En | MEDLINE | ID: mdl-36979543
Urinary chloride concentration is a valuable health metric that can aid in the early detection of serious conditions, such as acid base disorders, acute heart failure, and incidences of acute renal failure in the intensive care unit. Physiologically, urinary chloride levels frequently change and are difficult to measure, involving time-consuming and inconvenient lab testing. Thus, near real-time simple sensors are needed to quickly provide actionable data to inform diagnostic and treatment decisions that affect health outcomes. Here, we introduce a chronopotentiometric sensor that utilizes commercially available screen-printed electrodes to accurately quantify clinically relevant chloride concentrations (5-250 mM) in seconds, with no added reagents or electrode surface modification. Initially, the sensor's performance was optimized through the proper selection of current density at a specific chloride concentration, using electrical response data in conjunction with scanning electron microscopy. We developed a unique swept current density algorithm to resolve the entire clinically relevant chloride concentration range, and the chloride sensors can be reliably reused for chloride concentrations less than 50 mM. Lastly, we explored the impact of pH, temperature, conductivity, and additional ions (i.e., artificial urine) on the sensor signal, in order to determine sensor feasibility in complex biological samples. This study provides a path for further development of a portable, near real-time sensor for the quantification of urinary chloride.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloruros / Técnicas Electroquímicas Tipo de estudio: Prognostic_studies / Screening_studies Idioma: En Revista: Biosensors (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloruros / Técnicas Electroquímicas Tipo de estudio: Prognostic_studies / Screening_studies Idioma: En Revista: Biosensors (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza