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Transcriptomic effects of Perfluoralkyl acids on the adipose tissue of a songbird species at environmentally relevant concentrations.
Lopez-Antia, Ana; Piña, Benjamin; Lacorte, Silvia; Bervoets, Lieven; Eens, Marcel.
Afiliación
  • Lopez-Antia A; Behavioural Ecology and Ecophysiology Group (BECO), Department of Biology, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. Electronic address: Ana.lopezantia@idaea.csic.es.
  • Piña B; Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034, Barcelona, Catalonia, Spain. Electronic address: bpcbmc@cid.csic.es.
  • Lacorte S; Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034, Barcelona, Catalonia, Spain. Electronic address: Silvia.lacorte@idaea.csic.es.
  • Bervoets L; ECOSPHERE, Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020, Antwerp, Belgium. Electronic address: lieven.bervoets@uantwerpen.be.
  • Eens M; Behavioural Ecology and Ecophysiology Group (BECO), Department of Biology, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. Electronic address: marcel.eens@uantwerpen.be.
Environ Pollut ; 327: 121478, 2023 Jun 15.
Article en En | MEDLINE | ID: mdl-36972811
Perfluoralkyl acids (PFAS) have been regarded as global pollutants for at least twenty years, with potentially negative physiological effects on multiple vertebrate species including humans. Here we analyze the effects of the administration of environmentally-relevant levels of PFAS on caged canaries (Serinus canaria) by using a combination of physiological, immunological, and transcriptomic analyses. This constitutes a completely new approach to understand the toxicity pathway of PFAS in birds. While we observed no effects on physiological and immunological parameters (e.g, body weight, fat index, cell-mediated immunity), the transcriptome of the pectoral fatty tissue showed changes compatible with the known effects of PFAS as obesogens in other vertebrates, particularly in mammals. First, transcripts related to the immunological response were affected (mainly enriched), including several key signaling pathways. Second, we found a repression of genes related to the peroxisome response and fatty acid metabolism. We interpret these results as indicative of the potential hazard of environmental concentrations of PFAS on the fat metabolism and the immunological system of birds, while exemplifying the ability of transcriptomic analyses of detecting early physiological responses to toxicants. As the potentially affected functions are essential for the survival of the animals during, for example, migration, our results underline the need for tight control of the exposure of natural populations of birds to these substances.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Alcanesulfónicos / Pájaros Cantores / Contaminantes Ambientales / Fluorocarburos Límite: Animals / Humans Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Alcanesulfónicos / Pájaros Cantores / Contaminantes Ambientales / Fluorocarburos Límite: Animals / Humans Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido