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Examining attention-deficit/hyperactivity disorder and related behavioral disorders by fertility treatment exposure in a prospective cohort.
Yeung, Edwina H; Putnick, Diane L; Ghassabian, Akhgar; Sundaram, Rajeshwari; Lin, Tzu-Chun; Mirzaei, Sedigheh; Stern, Judy E; Bell, Erin.
Afiliación
  • Yeung EH; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Bethesda, MD. Electronic address: edwina.yeung@nih.gov.
  • Putnick DL; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Bethesda, MD.
  • Ghassabian A; Departments of Pediatrics, Environmental Medicine and Population Health, New York University Grossman School of Medicine, 227 East 30th Street, New York.
  • Sundaram R; Biostatistics and Bioinformatics Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Bethesda, MD.
  • Lin TC; Glotech, Inc., 1801 Research Boulevard #605, Rockville, MD.
  • Mirzaei S; Department of Biostatistics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Room R6002, Memphis, TN.
  • Stern JE; Department of Ob/Gyn, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH.
  • Bell E; Departments of Environmental Health Sciences and of Epidemiology and Biostatistics, University at Albany School of Public Health, 1400 Washington Avenue, Albany, NY.
Ann Epidemiol ; 82: 59-65.e1, 2023 06.
Article en En | MEDLINE | ID: mdl-36972758
PURPOSE: To evaluate whether underlying infertility and mode of conception are associated with childhood behavioral disorders. METHODS: Oversampling on fertility treatment exposure using vital records, the Upstate KIDS Study followed 2057 children (of 1754 mothers) from birth to 11 years. Type of fertility treatment and time to pregnancy (TTP) were self-reported. Mothers completed annual questionnaires reporting symptomology, diagnoses, and medications at 7-11 years of age. The information identified children with probable attention-deficit/hyperactivity disorder, anxiety or depression, and conduct or oppositional defiant disorders. We estimated adjusted relative risks (aRR) for disorders by underlying infertility (TTP > 12 months) or treatment exposure groups compared to children born to parents with TTP ≤ 12 months. RESULTS: Children conceived with fertility treatment (34%) did not have an increased risk of attention-deficit/hyperactivity disorder (aRR): 1.21; 95% CI: 0.88, 1.65), or conduct or oppositional defiant disorders (aRR: 1.31; 0.91, 1.86), but did have an increased risk of anxiety or depression (aRR: 1.63; 1.18, 2.24), which remained elevated even after adjusting for parental mood disorders (aRR: 1.40; 0.99, 1.96). Underlying infertility without the use of treatment was also associated with a risk of anxiety or depression (aRR: 1.82; 95% CI: 0.96, 3.43). CONCLUSIONS: Underlying infertility or its treatment was not associated with risk of attention-deficit/hyperactivity disorder. Observations of increased anxiety or depression require replication.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Trastorno de la Conducta / Infertilidad Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Child / Female / Humans / Pregnancy Idioma: En Revista: Ann Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Trastorno de la Conducta / Infertilidad Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Child / Female / Humans / Pregnancy Idioma: En Revista: Ann Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos